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VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of T(H)17 cells

The focus of this study is the characterization of human T cell blood–brain barrier migration and corresponding molecular trafficking signatures. We examined peripheral blood and cerebrospinal fluid immune cells from patients under long-term anti–very late antigen-4 (VLA-4)/natalizumab therapy (LTNT...

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Detalles Bibliográficos
Autores principales:	Schneider-Hohendorf, Tilman, Rossaint, Jan, Mohan, Hema, Böning, Daniel, Breuer, Johanna, Kuhlmann, Tanja, Gross, Catharina C., Flanagan, Ken, Sorokin, Lydia, Vestweber, Dietmar, Zarbock, Alexander, Schwab, Nicholas, Wiendl, Heinz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144733/ https://www.ncbi.nlm.nih.gov/pubmed/25135296 http://dx.doi.org/10.1084/jem.20140540

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