Enediyne Polyketide Synthases Stereoselectively Reduce the β-Ketoacyl Intermediates to β-d-Hydroxyacyl Intermediates in Enediyne Core Biosynthesis

[Image: see text] PKSE biosynthesizes an enediyne core precursor from decarboxylative condensation of eight malonyl-CoAs. The KR domain of PKSE is responsible for iterative β-ketoreduction in each round of polyketide chain elongation. KRs from selected PKSEs were investigated in vitro with β-ketoacy...

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Detalles Bibliográficos
Autores principales: Ge, Hui-Ming, Huang, Tingting, Rudolf, Jeffrey D., Lohman, Jeremy R., Huang, Sheng-Xiong, Guo, Xun, Shen, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144755/
https://www.ncbi.nlm.nih.gov/pubmed/25019332
http://dx.doi.org/10.1021/ol501767v

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144755/
https://www.ncbi.nlm.nih.gov/pubmed/25019332
http://dx.doi.org/10.1021/ol501767v

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