In Vitro Generation of Neuromesodermal Progenitors Reveals Distinct Roles for Wnt Signalling in the Specification of Spinal Cord and Paraxial Mesoderm Identity

Cells of the spinal cord and somites arise from shared, dual-fated precursors, located towards the posterior of the elongating embryo. Here we show that these neuromesodermal progenitors (NMPs) can readily be generated in vitro from mouse and human pluripotent stem cells by activating Wnt and Fgf si...

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Detalles Bibliográficos
Autores principales: Gouti, Mina, Tsakiridis, Anestis, Wymeersch, Filip J., Huang, Yali, Kleinjung, Jens, Wilson, Valerie, Briscoe, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144800/
https://www.ncbi.nlm.nih.gov/pubmed/25157815
http://dx.doi.org/10.1371/journal.pbio.1001937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144800/
https://www.ncbi.nlm.nih.gov/pubmed/25157815
http://dx.doi.org/10.1371/journal.pbio.1001937

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