Increased Presence of FOXP3(+) Regulatory T Cells in Inflamed Muscle of Patients with Active Juvenile Dermatomyositis Compared to Peripheral Blood

Juvenile dermatomyositis (JDM) is an immune-mediated inflammatory disease affecting the microvasculature of skin and muscle. CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) are key regulators of immune homeostasis. A role for Tregs in JDM pathogenesis has not yet been established. Here, we explored...

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Detalles Bibliográficos
Autores principales: Vercoulen, Yvonne, Bellutti Enders, Felicitas, Meerding, Jenny, Plantinga, Maud, Elst, Elisabeth F., Varsani, Hemlata, van Schieveen, Christa, Bakker, Mette H., Klein, Mark, Scholman, Rianne C., Spliet, Wim, Ricotti, Valeria, Koenen, Hans J. P. M., de Weger, Roel A., Wedderburn, Lucy R., van Royen-Kerkhof, Annet, Prakken, Berent J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144849/
https://www.ncbi.nlm.nih.gov/pubmed/25157414
http://dx.doi.org/10.1371/journal.pone.0105353

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