Do Breast Cancer Cell Lines Provide a Relevant Model of the Patient Tumor Methylome?

It is well documented that tumor cells undergo dramatic genetic and epigenetic changes during initial establishment as cell lines and in subsequent serial passaging, and that the resultant cell lines may have evolved significantly from the primary tumors from which they were derived. This has potent...

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Detalles Bibliográficos
Autores principales: Cope, Leslie M., Fackler, Mary Jo, Lopez-Bujanda, Zoila, Wolff, Antonio C., Visvanathan, Kala, Gray, Joe W., Sukumar, Saraswati, Umbricht, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144876/
https://www.ncbi.nlm.nih.gov/pubmed/25157401
http://dx.doi.org/10.1371/journal.pone.0105545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144876/
https://www.ncbi.nlm.nih.gov/pubmed/25157401
http://dx.doi.org/10.1371/journal.pone.0105545

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