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Do Breast Cancer Cell Lines Provide a Relevant Model of the Patient Tumor Methylome?
It is well documented that tumor cells undergo dramatic genetic and epigenetic changes during initial establishment as cell lines and in subsequent serial passaging, and that the resultant cell lines may have evolved significantly from the primary tumors from which they were derived. This has potent...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144876/ https://www.ncbi.nlm.nih.gov/pubmed/25157401 http://dx.doi.org/10.1371/journal.pone.0105545 |