Cargando…

Notch Inhibits Yorkie Activity in Drosophila Wing Discs

During development, tissues and organs must coordinate growth and patterning so they reach the right size and shape. During larval stages, a dramatic increase in size and cell number of Drosophila wing imaginal discs is controlled by the action of several signaling pathways. Complex cross-talk betwe...

Descripción completa

Detalles Bibliográficos
Autores principales: Djiane, Alexandre, Zaessinger, Sophie, Babaoğlan, A. Burcu, Bray, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144958/
https://www.ncbi.nlm.nih.gov/pubmed/25157415
http://dx.doi.org/10.1371/journal.pone.0106211
_version_ 1782332107966644224
author Djiane, Alexandre
Zaessinger, Sophie
Babaoğlan, A. Burcu
Bray, Sarah J.
author_facet Djiane, Alexandre
Zaessinger, Sophie
Babaoğlan, A. Burcu
Bray, Sarah J.
author_sort Djiane, Alexandre
collection PubMed
description During development, tissues and organs must coordinate growth and patterning so they reach the right size and shape. During larval stages, a dramatic increase in size and cell number of Drosophila wing imaginal discs is controlled by the action of several signaling pathways. Complex cross-talk between these pathways also pattern these discs to specify different regions with different fates and growth potentials. We show that the Notch signaling pathway is both required and sufficient to inhibit the activity of Yorkie (Yki), the Salvador/Warts/Hippo (SWH) pathway terminal transcription activator, but only in the central regions of the wing disc, where the TEAD factor and Yki partner Scalloped (Sd) is expressed. We show that this cross-talk between the Notch and SWH pathways is mediated, at least in part, by the Notch target and Sd partner Vestigial (Vg). We propose that, by altering the ratios between Yki, Sd and Vg, Notch pathway activation restricts the effects of Yki mediated transcription, therefore contributing to define a zone of low proliferation in the central wing discs.
format Online
Article
Text
id pubmed-4144958
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-41449582014-08-29 Notch Inhibits Yorkie Activity in Drosophila Wing Discs Djiane, Alexandre Zaessinger, Sophie Babaoğlan, A. Burcu Bray, Sarah J. PLoS One Research Article During development, tissues and organs must coordinate growth and patterning so they reach the right size and shape. During larval stages, a dramatic increase in size and cell number of Drosophila wing imaginal discs is controlled by the action of several signaling pathways. Complex cross-talk between these pathways also pattern these discs to specify different regions with different fates and growth potentials. We show that the Notch signaling pathway is both required and sufficient to inhibit the activity of Yorkie (Yki), the Salvador/Warts/Hippo (SWH) pathway terminal transcription activator, but only in the central regions of the wing disc, where the TEAD factor and Yki partner Scalloped (Sd) is expressed. We show that this cross-talk between the Notch and SWH pathways is mediated, at least in part, by the Notch target and Sd partner Vestigial (Vg). We propose that, by altering the ratios between Yki, Sd and Vg, Notch pathway activation restricts the effects of Yki mediated transcription, therefore contributing to define a zone of low proliferation in the central wing discs. Public Library of Science 2014-08-26 /pmc/articles/PMC4144958/ /pubmed/25157415 http://dx.doi.org/10.1371/journal.pone.0106211 Text en © 2014 Djiane et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Djiane, Alexandre
Zaessinger, Sophie
Babaoğlan, A. Burcu
Bray, Sarah J.
Notch Inhibits Yorkie Activity in Drosophila Wing Discs
title Notch Inhibits Yorkie Activity in Drosophila Wing Discs
title_full Notch Inhibits Yorkie Activity in Drosophila Wing Discs
title_fullStr Notch Inhibits Yorkie Activity in Drosophila Wing Discs
title_full_unstemmed Notch Inhibits Yorkie Activity in Drosophila Wing Discs
title_short Notch Inhibits Yorkie Activity in Drosophila Wing Discs
title_sort notch inhibits yorkie activity in drosophila wing discs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144958/
https://www.ncbi.nlm.nih.gov/pubmed/25157415
http://dx.doi.org/10.1371/journal.pone.0106211
work_keys_str_mv AT djianealexandre notchinhibitsyorkieactivityindrosophilawingdiscs
AT zaessingersophie notchinhibitsyorkieactivityindrosophilawingdiscs
AT babaoglanaburcu notchinhibitsyorkieactivityindrosophilawingdiscs
AT braysarahj notchinhibitsyorkieactivityindrosophilawingdiscs