USP33, a new player in lung cancer, mediates Slit-Robo signaling

Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP...

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Autores principales: Wen, Pushuai, Kong, Ruirui, Liu, Jianghong, Zhu, Li, Chen, Xiaoping, Li, Xiaofei, Nie, Yongzhan, Wu, Kaichun, Wu, Jane Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145083/
https://www.ncbi.nlm.nih.gov/pubmed/24981056
http://dx.doi.org/10.1007/s13238-014-0070-z
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author Wen, Pushuai
Kong, Ruirui
Liu, Jianghong
Zhu, Li
Chen, Xiaoping
Li, Xiaofei
Nie, Yongzhan
Wu, Kaichun
Wu, Jane Y.
author_facet Wen, Pushuai
Kong, Ruirui
Liu, Jianghong
Zhu, Li
Chen, Xiaoping
Li, Xiaofei
Nie, Yongzhan
Wu, Kaichun
Wu, Jane Y.
author_sort Wen, Pushuai
collection PubMed
description Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13238-014-0070-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-41450832014-08-28 USP33, a new player in lung cancer, mediates Slit-Robo signaling Wen, Pushuai Kong, Ruirui Liu, Jianghong Zhu, Li Chen, Xiaoping Li, Xiaofei Nie, Yongzhan Wu, Kaichun Wu, Jane Y. Protein Cell Research Article Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s13238-014-0070-z) contains supplementary material, which is available to authorized users. Higher Education Press 2014-07-02 2014-09 /pmc/articles/PMC4145083/ /pubmed/24981056 http://dx.doi.org/10.1007/s13238-014-0070-z Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Research Article
Wen, Pushuai
Kong, Ruirui
Liu, Jianghong
Zhu, Li
Chen, Xiaoping
Li, Xiaofei
Nie, Yongzhan
Wu, Kaichun
Wu, Jane Y.
USP33, a new player in lung cancer, mediates Slit-Robo signaling
title USP33, a new player in lung cancer, mediates Slit-Robo signaling
title_full USP33, a new player in lung cancer, mediates Slit-Robo signaling
title_fullStr USP33, a new player in lung cancer, mediates Slit-Robo signaling
title_full_unstemmed USP33, a new player in lung cancer, mediates Slit-Robo signaling
title_short USP33, a new player in lung cancer, mediates Slit-Robo signaling
title_sort usp33, a new player in lung cancer, mediates slit-robo signaling
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145083/
https://www.ncbi.nlm.nih.gov/pubmed/24981056
http://dx.doi.org/10.1007/s13238-014-0070-z
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