Clinical evaluation of the efficacy of methylnaltrexone in resolving constipation induced by different opioid subtypes combined with laboratory analysis of immunomodulatory and antiangiogenic effects of methylnaltrexone

BACKGROUND: Opioid-induced constipation (OIC) is one of the major symptoms in palliative care with a prevalence of 30-50%. Methylnaltrexone for the treatment of OIC is significantly more effective than placebo, but only in about fifty percent of the patients regardless of dose increase. Dose increas...

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Detalles Bibliográficos
Autores principales: Neefjes, Elisabeth CW, van der Vorst, Maurice JDL, Boddaert, Manon SA, Zuurmond, Wouter WA, van der Vliet, Hans J, Beeker, Aart, van den Berg, Hendrik P, van Groeningen, Cornelis J, Vrijaldenhoven, Suzan, Verheul, Henk MW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145161/
https://www.ncbi.nlm.nih.gov/pubmed/25165428
http://dx.doi.org/10.1186/1472-684X-13-42

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