Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients

The human genome contains a large number of endogenous retroviruses (HERVs). Their reactivation has frequently been observed in patients with cancer. Considering their role in the carcinogenesis process, we aimed to study the possible relationship between HERVs gene expression and Chronic Lymphocyti...

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Autores principales: Fischer, Sabrina, Echeverría, Natalia, Moratorio, Gonzalo, Landoni, Ana Inés, Dighiero, Guillermo, Cristina, Juan, Oppezzo, Pablo, Moreno, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145164/
https://www.ncbi.nlm.nih.gov/pubmed/25180156
http://dx.doi.org/10.1016/j.lrr.2014.06.005
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author Fischer, Sabrina
Echeverría, Natalia
Moratorio, Gonzalo
Landoni, Ana Inés
Dighiero, Guillermo
Cristina, Juan
Oppezzo, Pablo
Moreno, Pilar
author_facet Fischer, Sabrina
Echeverría, Natalia
Moratorio, Gonzalo
Landoni, Ana Inés
Dighiero, Guillermo
Cristina, Juan
Oppezzo, Pablo
Moreno, Pilar
author_sort Fischer, Sabrina
collection PubMed
description The human genome contains a large number of endogenous retroviruses (HERVs). Their reactivation has frequently been observed in patients with cancer. Considering their role in the carcinogenesis process, we aimed to study the possible relationship between HERVs gene expression and Chronic Lymphocytic Leukemia (CLL). We focused on two viral genes gag and np9, the latter presumably an oncogene. We found that the transcriptional activity of HERV-K np9 gene was greater in CLL patients than in healthy donors. However, gag expression was not significantly increased. These findings suggest a noteworthy relationship between CLL disease and HERV-K np9 expression.
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spelling pubmed-41451642014-09-01 Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients Fischer, Sabrina Echeverría, Natalia Moratorio, Gonzalo Landoni, Ana Inés Dighiero, Guillermo Cristina, Juan Oppezzo, Pablo Moreno, Pilar Leuk Res Rep Article The human genome contains a large number of endogenous retroviruses (HERVs). Their reactivation has frequently been observed in patients with cancer. Considering their role in the carcinogenesis process, we aimed to study the possible relationship between HERVs gene expression and Chronic Lymphocytic Leukemia (CLL). We focused on two viral genes gag and np9, the latter presumably an oncogene. We found that the transcriptional activity of HERV-K np9 gene was greater in CLL patients than in healthy donors. However, gag expression was not significantly increased. These findings suggest a noteworthy relationship between CLL disease and HERV-K np9 expression. Elsevier 2014-07-25 /pmc/articles/PMC4145164/ /pubmed/25180156 http://dx.doi.org/10.1016/j.lrr.2014.06.005 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Fischer, Sabrina
Echeverría, Natalia
Moratorio, Gonzalo
Landoni, Ana Inés
Dighiero, Guillermo
Cristina, Juan
Oppezzo, Pablo
Moreno, Pilar
Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients
title Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients
title_full Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients
title_fullStr Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients
title_full_unstemmed Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients
title_short Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients
title_sort human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145164/
https://www.ncbi.nlm.nih.gov/pubmed/25180156
http://dx.doi.org/10.1016/j.lrr.2014.06.005
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