Targeted metabolomic analysis of amino acid response to L-asparaginase in adherent cells

L-asparaginase (L-ASP) is a therapeutic enzyme used clinically for the treatment of childhood acute lymphoblastic leukemia. L-ASP’s anticancer activity is believed to be associated primarily with depletion of asparagine, but secondary glutaminase activity has also been implicated in its anticancer m...

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Detalles Bibliográficos
Autores principales: Purwaha, Preeti, Lorenzi, Philip L., Silva, Leslie P., Hawke, David H., Weinstein, John N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145215/
https://www.ncbi.nlm.nih.gov/pubmed/25177232
http://dx.doi.org/10.1007/s11306-014-0634-1

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