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Targeted metabolomic analysis of amino acid response to L-asparaginase in adherent cells
L-asparaginase (L-ASP) is a therapeutic enzyme used clinically for the treatment of childhood acute lymphoblastic leukemia. L-ASP’s anticancer activity is believed to be associated primarily with depletion of asparagine, but secondary glutaminase activity has also been implicated in its anticancer m...
Autores principales: | Purwaha, Preeti, Lorenzi, Philip L., Silva, Leslie P., Hawke, David H., Weinstein, John N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145215/ https://www.ncbi.nlm.nih.gov/pubmed/25177232 http://dx.doi.org/10.1007/s11306-014-0634-1 |
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