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MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1

BACKGROUND: The IFN-α-inducible restriction factor MxB blocks HIV-1 infection after reverse transcription but prior to integration. Genetic evidence suggested that capsid is the viral determinant for restriction by MxB. This work explores the ability of MxB to bind to the HIV-1 core, and the role of...

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Detalles Bibliográficos
Autores principales:	Fricke, Thomas, White, Tommy E, Schulte, Bianca, de Souza Aranha Vieira, Daniel A, Dharan, Adarsh, Campbell, Edward M, Brandariz-Nuñez, Alberto, Diaz-Griffero, Felipe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145229/ https://www.ncbi.nlm.nih.gov/pubmed/25123063 http://dx.doi.org/10.1186/s12977-014-0068-x

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