High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors

BACKGROUND: The treatment of human cancer has been seriously hampered for decades by resistance to chemotherapeutic drugs. A very efficient mechanism of tumor resistance to drugs is the proton pumps-mediated acidification of tumor microenvironment. Metronomic chemotherapy has shown efficacy in adjuv...

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Detalles Bibliográficos
Autores principales: Spugnini, Enrico P, Buglioni, Sabrina, Carocci, Francesca, Francesco, Menicagli, Vincenzi, Bruno, Fanciulli, Maurizio, Fais, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145230/
https://www.ncbi.nlm.nih.gov/pubmed/25143012
http://dx.doi.org/10.1186/s12967-014-0225-y

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