Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer

BACKGROUND: Gastric cancer is the second-leading cause of global cancer deaths, with metastatic disease representing the primary cause of mortality. To identify candidate drivers involved in oncogenesis and tumor evolution, we conduct an extensive genome sequencing analysis of metastatic progression...

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Detalles Bibliográficos
Autores principales: Nadauld, Lincoln D, Garcia, Sarah, Natsoulis, Georges, Bell, John M, Miotke, Laura, Hopmans, Erik S, Xu, Hua, Pai, Reetesh K, Palm, Curt, Regan, John F, Chen, Hao, Flaherty, Patrick, Ootani, Akifumi, Zhang, Nancy R, Ford, James M, Kuo, Calvin J, Ji, Hanlee P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145231/
https://www.ncbi.nlm.nih.gov/pubmed/25315765
http://dx.doi.org/10.1186/s13059-014-0428-9

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