Cargando…

Persistent pharmacokinetic challenges to pediatric drug development

The development of new therapeutic agents for the mitigation of pediatric disorders is largely hindered by the inability for investigators to assess pediatric pharmacokinetics (PK) in healthy patients due to substantial safety concerns. Pediatric patients are a clinical moving target for drug delive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sage, Daniel P., Kulczar, Christopher, Roth, Wyatt, Liu, Wanqing, Knipp, Gregory T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145254/ https://www.ncbi.nlm.nih.gov/pubmed/25221567 http://dx.doi.org/10.3389/fgene.2014.00281

Ejemplares similares

Pharmacogenomics of acetaminophen in pediatric populations: a moving target
por: Krasniak, Anne E., et al.
Publicado: (2014)

Treatment of Acute Myeloid Leukemia in the Era of Genomics—Achievements and Persisting Challenges
por: Green, Steven D., et al.
Publicado: (2020)

The Challenges of Pediatric Drug Development
por: Rose, Klaus
Publicado: (2019)

Non-Coding RNAs in Pediatric Solid Tumors
por: Smith, Christopher M., et al.
Publicado: (2019)

Does Cannabis Intake Protect Against Non-alcoholic Fatty Liver Disease? A Two-Sample Mendelian Randomization Study
por: Wang, Xiaokun, et al.
Publicado: (2020)

Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
por: Maharaj, A R, et al.
Publicado: (2014)

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens
por: Limonciel, Alice, et al.
Publicado: (2018)

Pediatric Drug Development: Challenges and Opportunities
por: Spadoni, Cesare
Publicado: (2018)

Application of Pharmacokinetic-Pharmacodynamic Modeling in Drug Delivery: Development and Challenges
por: Zou, Huixi, et al.
Publicado: (2020)

Pharmacokinetics and Genetic Factors of Atorvastatin in Healthy Korean Subjects
por: Kim, Serim, et al.
Publicado: (2022)

Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development
por: Wang, Kefei, et al.
Publicado: (2021)

Editorial: Epigenetics in Cancer: Mechanisms and Drug Development
por: Yuan, Huiqing, et al.
Publicado: (2022)

Beyond Single Nucleotide Polymorphisms: CYP3A5(∗)3(∗)6(∗)7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients
por: Brazeau, Daniel A., et al.
Publicado: (2020)

Human Organoids for Predictive Toxicology Research and Drug Development
por: Matsui, Toshikatsu, et al.
Publicado: (2021)

Development and Validation of a Five-RNA–Based Signature and Identification of Candidate Drugs for Neuroblastoma
por: Zhang, PeiPei, et al.
Publicado: (2021)

Sharing and Safeguarding Pediatric Data
por: Patrinos, Dimitri, et al.
Publicado: (2022)

The Challenges of Microbial Control of Mosquito-Borne Diseases Due to the Gut Microbiome
por: Dacey, Daniel P., et al.
Publicado: (2020)

RNA-Sequencing of Primary Retinoblastoma Tumors Provides New Insights and Challenges Into Tumor Development
por: Elchuri, Sailaja V., et al.
Publicado: (2018)

Tracing the Distribution of European Lactase Persistence Genotypes Along the Americas
por: Guimarães Alves, Ana Cecília, et al.
Publicado: (2021)

Analysis of Genome-Wide Alternative Splicing Profiling and Development of Potential Drugs in Lung Adenocarcinoma
por: Song, Jing, et al.
Publicado: (2021)

Association of the Lactase Persistence Haplotype Block With Disease Risk in Populations of European Descent
por: Joslin, Shannon E. K., et al.
Publicado: (2020)

Editorial: Epigenetics in cancer: mechanisms and drug development-volume II
por: Zhu, Xiao, et al.
Publicado: (2023)

Microrefugia and species persistence in the Galápagos highlands: a 26,000-year paleoecological perspective
por: Collins, Aaron F., et al.
Publicado: (2013)

Pharmacokinetic–Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance
por: Germovsek, Eva, et al.
Publicado: (2018)

Developing a non-invasive diagnostic model for pediatric Crohn’s disease using RNA-seq analysis
por: He, Bin, et al.
Publicado: (2023)

Association between hTERT rs2736100 polymorphism and sensitivity to anti-cancer agents
por: Kim, Julie, et al.
Publicado: (2013)

Five-Feature Model for Developing the Classifier for Synergistic vs. Antagonistic Drug Combinations Built by XGBoost
por: Ji, Xiangjun, et al.
Publicado: (2019)

The Emerging Role of Non-Coding RNAs in Drug Addiction
por: Sartor, Gregory C., et al.
Publicado: (2012)

Targeting STAT-3 signaling pathway in cancer for development of novel drugs: Advancements and challenges
por: Arshad, Sundas, et al.
Publicado: (2020)

Potential value of the homologous recombination deficiency signature we developed in the prognosis and drug sensitivity of gastric cancer
por: Wu, Xin, et al.
Publicado: (2022)

Persistent Activation of the Innate Immune Response in Adult Drosophila Following Radiation Exposure During Larval Development
por: Sudmeier, Lisa J., et al.
Publicado: (2015)

Impact of the Interaction between 3′-UTR SNPs and microRNA on the Expression of Human Xenobiotic Metabolism Enzyme and Transporter Genes
por: Wei, Rongrong, et al.
Publicado: (2012)

An Improved Deep Learning Model: S-TextBLCNN for Traditional Chinese Medicine Formula Classification
por: Cheng, Ning, et al.
Publicado: (2021)

Gene Set Analysis: Challenges, Opportunities, and Future Research
por: Maleki, Farhad, et al.
Publicado: (2020)

The molecular mechanisms of CTHRC1 in gastric cancer by integrating TCGA, GEO and GSA datasets
por: Zhao, Lulu, et al.
Publicado: (2022)

Genome-Scale Metabolic Modeling of Glioblastoma Reveals Promising Targets for Drug Development
por: Larsson, Ida, et al.
Publicado: (2020)

The challenges and importance of structural variation detection in livestock
por: Bickhart, Derek M., et al.
Publicado: (2014)

Identifying ceRNA Networks Associated With the Susceptibility and Persistence of Atrial Fibrillation Through Weighted Gene Co-Expression Network Analysis
por: Liu, Yaozhong, et al.
Publicado: (2021)

Potentials and challenges of chromosomal microarray analysis in prenatal diagnosis
por: Liu, Xijing, et al.
Publicado: (2022)

No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants
por: Cai, Na, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_4bv8h83pr8uhajnu7l0jm7usc1