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Iatrogenic cushing's syndrome in children following nasal steroid

Cushing syndrome is a hormonal disorder caused by prolonged exposure of body tissue to cortisol. We report two cases of iatrogenic Cushing's syndrome in two Nigerian children following intranasal administration of aristobed-N (Betamethasone + Neomycin) given at a private hospital where the chil...

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Autores principales: Oluwayemi, Isaac Oludare, Oduwole, Abiola Olufunmilayo, Oyenusi, Elizabeth, Onyiriuka, Alphonsus Ndidi, Abdullahi, Muhammad, Fakeye-Udeogu, Olubunmi Benedicta, Achonwa, Chidozie Jude, Kouyate, Moustapha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145270/
https://www.ncbi.nlm.nih.gov/pubmed/25170381
http://dx.doi.org/10.11604/pamj.2014.17.237.3332
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author Oluwayemi, Isaac Oludare
Oduwole, Abiola Olufunmilayo
Oyenusi, Elizabeth
Onyiriuka, Alphonsus Ndidi
Abdullahi, Muhammad
Fakeye-Udeogu, Olubunmi Benedicta
Achonwa, Chidozie Jude
Kouyate, Moustapha
author_facet Oluwayemi, Isaac Oludare
Oduwole, Abiola Olufunmilayo
Oyenusi, Elizabeth
Onyiriuka, Alphonsus Ndidi
Abdullahi, Muhammad
Fakeye-Udeogu, Olubunmi Benedicta
Achonwa, Chidozie Jude
Kouyate, Moustapha
author_sort Oluwayemi, Isaac Oludare
collection PubMed
description Cushing syndrome is a hormonal disorder caused by prolonged exposure of body tissue to cortisol. We report two cases of iatrogenic Cushing's syndrome in two Nigerian children following intranasal administration of aristobed-N (Betamethasone + Neomycin) given at a private hospital where the children presented with feature of adenoidal hypertrophy. Two months into treatment children were noticed to have developed clinical and laboratory features of iatrogenic Cushing's syndrome with critical adrenal suppression. Serum cortisol (at presentation): 1(st) patient: 12nmol/L (reference range 240-618), 2(nd) Patient: 1.69nmol/L. Serum cortisol (3 months after weaning off steroid): 343.27 nmol/L (within normal range for the first patient; second patient newly presented and has just begun steroid weaning off process. The serum cortisol level one month into weaninig off process was 128 nmol/L). Unsupervised topical steroid administration in children can cause adrenal suppression with clinical features of Cushing's syndrome.
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spelling pubmed-41452702014-08-28 Iatrogenic cushing's syndrome in children following nasal steroid Oluwayemi, Isaac Oludare Oduwole, Abiola Olufunmilayo Oyenusi, Elizabeth Onyiriuka, Alphonsus Ndidi Abdullahi, Muhammad Fakeye-Udeogu, Olubunmi Benedicta Achonwa, Chidozie Jude Kouyate, Moustapha Pan Afr Med J Case Report Cushing syndrome is a hormonal disorder caused by prolonged exposure of body tissue to cortisol. We report two cases of iatrogenic Cushing's syndrome in two Nigerian children following intranasal administration of aristobed-N (Betamethasone + Neomycin) given at a private hospital where the children presented with feature of adenoidal hypertrophy. Two months into treatment children were noticed to have developed clinical and laboratory features of iatrogenic Cushing's syndrome with critical adrenal suppression. Serum cortisol (at presentation): 1(st) patient: 12nmol/L (reference range 240-618), 2(nd) Patient: 1.69nmol/L. Serum cortisol (3 months after weaning off steroid): 343.27 nmol/L (within normal range for the first patient; second patient newly presented and has just begun steroid weaning off process. The serum cortisol level one month into weaninig off process was 128 nmol/L). Unsupervised topical steroid administration in children can cause adrenal suppression with clinical features of Cushing's syndrome. The African Field Epidemiology Network 2014-03-28 /pmc/articles/PMC4145270/ /pubmed/25170381 http://dx.doi.org/10.11604/pamj.2014.17.237.3332 Text en © Isaac Oludare Oluwayemi et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Oluwayemi, Isaac Oludare
Oduwole, Abiola Olufunmilayo
Oyenusi, Elizabeth
Onyiriuka, Alphonsus Ndidi
Abdullahi, Muhammad
Fakeye-Udeogu, Olubunmi Benedicta
Achonwa, Chidozie Jude
Kouyate, Moustapha
Iatrogenic cushing's syndrome in children following nasal steroid
title Iatrogenic cushing's syndrome in children following nasal steroid
title_full Iatrogenic cushing's syndrome in children following nasal steroid
title_fullStr Iatrogenic cushing's syndrome in children following nasal steroid
title_full_unstemmed Iatrogenic cushing's syndrome in children following nasal steroid
title_short Iatrogenic cushing's syndrome in children following nasal steroid
title_sort iatrogenic cushing's syndrome in children following nasal steroid
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145270/
https://www.ncbi.nlm.nih.gov/pubmed/25170381
http://dx.doi.org/10.11604/pamj.2014.17.237.3332
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