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Unbalanced Neonatal CD4(+) T-Cell Immunity
In comparison to adults, newborns display a heightened susceptibility to pathogens and a propensity to develop allergic diseases. Particular properties of the neonatal immune system can account for this sensitivity. Indeed, a defect in developing protective Th1-type responses and a skewing toward Th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145351/ https://www.ncbi.nlm.nih.gov/pubmed/25221551 http://dx.doi.org/10.3389/fimmu.2014.00393 |
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author | Debock, Isabelle Flamand, Véronique |
author_facet | Debock, Isabelle Flamand, Véronique |
author_sort | Debock, Isabelle |
collection | PubMed |
description | In comparison to adults, newborns display a heightened susceptibility to pathogens and a propensity to develop allergic diseases. Particular properties of the neonatal immune system can account for this sensitivity. Indeed, a defect in developing protective Th1-type responses and a skewing toward Th2 immunity characterize today the neonatal T-cell immunity. Recently, new findings concerning Th17, regulatory helper T-cell, and follicular helper T-cell subsets in newborns have emerged. In some circumstances, development of effector inflammatory Th17-type responses can be induced in neonates, while differentiation in regulatory T-cells appears to be a default program of neonatal CD4(+) T-cells. Poor antibody production, affinity maturation, and germinal center reaction in vaccinated neonates are correlated with a limiting expansion of T(FH) lymphocytes. We review herein the factors accounting for and the implications of the unbalanced neonatal helper T-cell immunity. |
format | Online Article Text |
id | pubmed-4145351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41453512014-09-12 Unbalanced Neonatal CD4(+) T-Cell Immunity Debock, Isabelle Flamand, Véronique Front Immunol Immunology In comparison to adults, newborns display a heightened susceptibility to pathogens and a propensity to develop allergic diseases. Particular properties of the neonatal immune system can account for this sensitivity. Indeed, a defect in developing protective Th1-type responses and a skewing toward Th2 immunity characterize today the neonatal T-cell immunity. Recently, new findings concerning Th17, regulatory helper T-cell, and follicular helper T-cell subsets in newborns have emerged. In some circumstances, development of effector inflammatory Th17-type responses can be induced in neonates, while differentiation in regulatory T-cells appears to be a default program of neonatal CD4(+) T-cells. Poor antibody production, affinity maturation, and germinal center reaction in vaccinated neonates are correlated with a limiting expansion of T(FH) lymphocytes. We review herein the factors accounting for and the implications of the unbalanced neonatal helper T-cell immunity. Frontiers Media S.A. 2014-08-27 /pmc/articles/PMC4145351/ /pubmed/25221551 http://dx.doi.org/10.3389/fimmu.2014.00393 Text en Copyright © 2014 Debock and Flamand. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Debock, Isabelle Flamand, Véronique Unbalanced Neonatal CD4(+) T-Cell Immunity |
title | Unbalanced Neonatal CD4(+) T-Cell Immunity |
title_full | Unbalanced Neonatal CD4(+) T-Cell Immunity |
title_fullStr | Unbalanced Neonatal CD4(+) T-Cell Immunity |
title_full_unstemmed | Unbalanced Neonatal CD4(+) T-Cell Immunity |
title_short | Unbalanced Neonatal CD4(+) T-Cell Immunity |
title_sort | unbalanced neonatal cd4(+) t-cell immunity |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145351/ https://www.ncbi.nlm.nih.gov/pubmed/25221551 http://dx.doi.org/10.3389/fimmu.2014.00393 |
work_keys_str_mv | AT debockisabelle unbalancedneonatalcd4tcellimmunity AT flamandveronique unbalancedneonatalcd4tcellimmunity |