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Fetal Stem Cells and Skeletal Muscle Regeneration: A Therapeutic Approach

More than 40% of the body mass is represented by muscle tissue, which possesses the innate ability to regenerate after damage through the activation of muscle-specific stem cells, namely satellite cells. Muscle diseases, in particular chronic degenerative states of skeletal muscle such as dystrophie...

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Autores principales: Pozzobon, Michela, Franzin, Chiara, Piccoli, Martina, De Coppi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145352/
https://www.ncbi.nlm.nih.gov/pubmed/25221507
http://dx.doi.org/10.3389/fnagi.2014.00222
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author Pozzobon, Michela
Franzin, Chiara
Piccoli, Martina
De Coppi, Paolo
author_facet Pozzobon, Michela
Franzin, Chiara
Piccoli, Martina
De Coppi, Paolo
author_sort Pozzobon, Michela
collection PubMed
description More than 40% of the body mass is represented by muscle tissue, which possesses the innate ability to regenerate after damage through the activation of muscle-specific stem cells, namely satellite cells. Muscle diseases, in particular chronic degenerative states of skeletal muscle such as dystrophies, lead to a perturbation of the regenerative process, which causes the premature exhaustion of satellite cell reservoir due to continuous cycles of degeneration/regeneration. Nowadays, the research is focused on different therapeutic approaches, ranging from gene and cell to pharmacological therapy, but still there is no definitive cure in particular for genetic muscle disease. Keeping this in mind, in this article, we will give special consideration to muscle diseases and the use of fetal derived stem cells as a new approach for therapy. Cells of fetal origin, from cord blood to placenta and amniotic fluid, can be easily obtained without ethical concern, expanded and differentiated in culture, and possess immune-modulatory properties. The in vivo approach in animal models can be helpful to study the mechanism underneath the operating principle of the stem cell reservoir, namely the niche, which holds great potential to understand the onset of muscle pathologies.
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spelling pubmed-41453522014-09-12 Fetal Stem Cells and Skeletal Muscle Regeneration: A Therapeutic Approach Pozzobon, Michela Franzin, Chiara Piccoli, Martina De Coppi, Paolo Front Aging Neurosci Neuroscience More than 40% of the body mass is represented by muscle tissue, which possesses the innate ability to regenerate after damage through the activation of muscle-specific stem cells, namely satellite cells. Muscle diseases, in particular chronic degenerative states of skeletal muscle such as dystrophies, lead to a perturbation of the regenerative process, which causes the premature exhaustion of satellite cell reservoir due to continuous cycles of degeneration/regeneration. Nowadays, the research is focused on different therapeutic approaches, ranging from gene and cell to pharmacological therapy, but still there is no definitive cure in particular for genetic muscle disease. Keeping this in mind, in this article, we will give special consideration to muscle diseases and the use of fetal derived stem cells as a new approach for therapy. Cells of fetal origin, from cord blood to placenta and amniotic fluid, can be easily obtained without ethical concern, expanded and differentiated in culture, and possess immune-modulatory properties. The in vivo approach in animal models can be helpful to study the mechanism underneath the operating principle of the stem cell reservoir, namely the niche, which holds great potential to understand the onset of muscle pathologies. Frontiers Media S.A. 2014-08-27 /pmc/articles/PMC4145352/ /pubmed/25221507 http://dx.doi.org/10.3389/fnagi.2014.00222 Text en Copyright © 2014 Pozzobon, Franzin, Piccoli and De Coppi. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Pozzobon, Michela
Franzin, Chiara
Piccoli, Martina
De Coppi, Paolo
Fetal Stem Cells and Skeletal Muscle Regeneration: A Therapeutic Approach
title Fetal Stem Cells and Skeletal Muscle Regeneration: A Therapeutic Approach
title_full Fetal Stem Cells and Skeletal Muscle Regeneration: A Therapeutic Approach
title_fullStr Fetal Stem Cells and Skeletal Muscle Regeneration: A Therapeutic Approach
title_full_unstemmed Fetal Stem Cells and Skeletal Muscle Regeneration: A Therapeutic Approach
title_short Fetal Stem Cells and Skeletal Muscle Regeneration: A Therapeutic Approach
title_sort fetal stem cells and skeletal muscle regeneration: a therapeutic approach
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145352/
https://www.ncbi.nlm.nih.gov/pubmed/25221507
http://dx.doi.org/10.3389/fnagi.2014.00222
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