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Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients
PURPOSE: To evaluate the corneal biomechanical properties due to the glycosylated hemoglobin (HbA1C) levels using the ocular response analyzer (ORA) in the patients with type 2 diabetes mellitus (DM). METHODS: ORA values were obtained from 156 eyes of subjects with type 2 DM and 74 eyes of healthy c...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145729/ https://www.ncbi.nlm.nih.gov/pubmed/25170249 http://dx.doi.org/10.2147/OPTH.S67984 |
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author | Yazgan, Serpil Celik, Ugur Kaldırım, Havva Ayar, Orhan Elbay, Ahmet Aykut, Veysel Celik, Burcu Taş, Mehmet |
author_facet | Yazgan, Serpil Celik, Ugur Kaldırım, Havva Ayar, Orhan Elbay, Ahmet Aykut, Veysel Celik, Burcu Taş, Mehmet |
author_sort | Yazgan, Serpil |
collection | PubMed |
description | PURPOSE: To evaluate the corneal biomechanical properties due to the glycosylated hemoglobin (HbA1C) levels using the ocular response analyzer (ORA) in the patients with type 2 diabetes mellitus (DM). METHODS: ORA values were obtained from 156 eyes of subjects with type 2 DM and 74 eyes of healthy control subjects with similar age and sex. Subjects were divided into three groups: Group 1, healthy control subjects; Group 2, diabetes patients with HbA1C <7%; and Group 3, diabetes patients with HbA1C ≥7%. Corneal biomechanical parameters: corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) measurements were obtained using ORA. Ultrasound pachymetry was used for measurement of central corneal thickness (CCT). RESULTS: CH and CRF were significantly different in each of the three groups (P-values for CH respectively; Groups 1 and 2=0.008, Groups 1 and 3, and Groups 2 and 3, <0.001, and for CRF respectively; =0.002, <0.001, <0.001). CCT was significantly different between Groups 1 and 3 and Groups 2 and 3 (P<0.001) but was insignificant between Groups 1 and 2 (P=0.965). IOPcc was not different between Groups 1 and 2 (P=0.524), and Groups 2 and 3 (P=0.115), but was significantly different between Groups 1 and 3 (P=0.003). IOPg was statistically different between each of the three groups (respectively; Groups 1 and 2, P=0.015, Groups 1 and 3, and Groups 2 and 3, P<0.001). CONCLUSION: Both diabetes groups were affected in terms of corneal biomechanical properties when compared to healthy subjects, there was also a positive correlation between HbA1C level and intraocular pressure. |
format | Online Article Text |
id | pubmed-4145729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-41457292014-08-28 Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients Yazgan, Serpil Celik, Ugur Kaldırım, Havva Ayar, Orhan Elbay, Ahmet Aykut, Veysel Celik, Burcu Taş, Mehmet Clin Ophthalmol Original Research PURPOSE: To evaluate the corneal biomechanical properties due to the glycosylated hemoglobin (HbA1C) levels using the ocular response analyzer (ORA) in the patients with type 2 diabetes mellitus (DM). METHODS: ORA values were obtained from 156 eyes of subjects with type 2 DM and 74 eyes of healthy control subjects with similar age and sex. Subjects were divided into three groups: Group 1, healthy control subjects; Group 2, diabetes patients with HbA1C <7%; and Group 3, diabetes patients with HbA1C ≥7%. Corneal biomechanical parameters: corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) measurements were obtained using ORA. Ultrasound pachymetry was used for measurement of central corneal thickness (CCT). RESULTS: CH and CRF were significantly different in each of the three groups (P-values for CH respectively; Groups 1 and 2=0.008, Groups 1 and 3, and Groups 2 and 3, <0.001, and for CRF respectively; =0.002, <0.001, <0.001). CCT was significantly different between Groups 1 and 3 and Groups 2 and 3 (P<0.001) but was insignificant between Groups 1 and 2 (P=0.965). IOPcc was not different between Groups 1 and 2 (P=0.524), and Groups 2 and 3 (P=0.115), but was significantly different between Groups 1 and 3 (P=0.003). IOPg was statistically different between each of the three groups (respectively; Groups 1 and 2, P=0.015, Groups 1 and 3, and Groups 2 and 3, P<0.001). CONCLUSION: Both diabetes groups were affected in terms of corneal biomechanical properties when compared to healthy subjects, there was also a positive correlation between HbA1C level and intraocular pressure. Dove Medical Press 2014-08-19 /pmc/articles/PMC4145729/ /pubmed/25170249 http://dx.doi.org/10.2147/OPTH.S67984 Text en © 2014 Yazgan et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Yazgan, Serpil Celik, Ugur Kaldırım, Havva Ayar, Orhan Elbay, Ahmet Aykut, Veysel Celik, Burcu Taş, Mehmet Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients |
title | Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients |
title_full | Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients |
title_fullStr | Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients |
title_full_unstemmed | Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients |
title_short | Evaluation of the relationship between corneal biomechanic and HbA1C levels in type 2 diabetes patients |
title_sort | evaluation of the relationship between corneal biomechanic and hba1c levels in type 2 diabetes patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145729/ https://www.ncbi.nlm.nih.gov/pubmed/25170249 http://dx.doi.org/10.2147/OPTH.S67984 |
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