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Protective effect of Jiaweibugan decoction against diabetic peripheral neuropathy☆

Oxygen free radical damage is regarded as a direct or indirect common pathway associated with diabetic neuropathy and is the main cause of complications in peripheral neuropathies. We speculate that Jiaweibugan decoction has a significant effect in treating diabetic peripheral neuropathy through an...

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Autores principales: Wang, Yu, Chen, Zeqi, Ye, Renqun, He, Yulei, Li, Yuhong, Qiu, Xinjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145893/
https://www.ncbi.nlm.nih.gov/pubmed/25206405
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.12.006
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author Wang, Yu
Chen, Zeqi
Ye, Renqun
He, Yulei
Li, Yuhong
Qiu, Xinjian
author_facet Wang, Yu
Chen, Zeqi
Ye, Renqun
He, Yulei
Li, Yuhong
Qiu, Xinjian
author_sort Wang, Yu
collection PubMed
description Oxygen free radical damage is regarded as a direct or indirect common pathway associated with diabetic neuropathy and is the main cause of complications in peripheral neuropathies. We speculate that Jiaweibugan decoction has a significant effect in treating diabetic peripheral neuropathy through an anti-oxidative stress pathway. In this study, a diabetic rat model was established by intraperitoneal injection of streptozotocin. Rats were treated with Jiaweibugan decoction via intragastric administration. The levels of malondialdehyde and glutathione, which are indirect indexes of oxidative stress, in serum were determined using a colorimetric method. The expression levels of nuclear factor kappa B p65 mRNA and p38 mitogen-activated protein kinase, which are oxidative stress associated factors, in the dorsal root ganglion of spinal S(4–6) segments were evaluated by reverse-transcriptase polymerase chain reaction and immunohistochemistry. Results showed that, Jiaweibugan decoction significantly ameliorated motor nerve conduction velocity in diabetic rats, effectively decreased malondialdehyde levels in serum and the expression of nuclear factor kappa B p65 mRNA and p38 mitogen-activated protein kinase mRNA in the dorsal root ganglion, and increased glutathione levels in serum. Therefore, our experimental findings indicate that Jiaweibugan decoction plays an anti-oxidative stress role in the diabetic peripheral neuropathy process, which has a protective effect on peripheral nerve injury.
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spelling pubmed-41458932014-09-09 Protective effect of Jiaweibugan decoction against diabetic peripheral neuropathy☆ Wang, Yu Chen, Zeqi Ye, Renqun He, Yulei Li, Yuhong Qiu, Xinjian Neural Regen Res Research and Report Article: Traditional Chinese Medicine and Neural Regeneration Oxygen free radical damage is regarded as a direct or indirect common pathway associated with diabetic neuropathy and is the main cause of complications in peripheral neuropathies. We speculate that Jiaweibugan decoction has a significant effect in treating diabetic peripheral neuropathy through an anti-oxidative stress pathway. In this study, a diabetic rat model was established by intraperitoneal injection of streptozotocin. Rats were treated with Jiaweibugan decoction via intragastric administration. The levels of malondialdehyde and glutathione, which are indirect indexes of oxidative stress, in serum were determined using a colorimetric method. The expression levels of nuclear factor kappa B p65 mRNA and p38 mitogen-activated protein kinase, which are oxidative stress associated factors, in the dorsal root ganglion of spinal S(4–6) segments were evaluated by reverse-transcriptase polymerase chain reaction and immunohistochemistry. Results showed that, Jiaweibugan decoction significantly ameliorated motor nerve conduction velocity in diabetic rats, effectively decreased malondialdehyde levels in serum and the expression of nuclear factor kappa B p65 mRNA and p38 mitogen-activated protein kinase mRNA in the dorsal root ganglion, and increased glutathione levels in serum. Therefore, our experimental findings indicate that Jiaweibugan decoction plays an anti-oxidative stress role in the diabetic peripheral neuropathy process, which has a protective effect on peripheral nerve injury. Medknow Publications & Media Pvt Ltd 2013-04-25 /pmc/articles/PMC4145893/ /pubmed/25206405 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.12.006 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report Article: Traditional Chinese Medicine and Neural Regeneration
Wang, Yu
Chen, Zeqi
Ye, Renqun
He, Yulei
Li, Yuhong
Qiu, Xinjian
Protective effect of Jiaweibugan decoction against diabetic peripheral neuropathy☆
title Protective effect of Jiaweibugan decoction against diabetic peripheral neuropathy☆
title_full Protective effect of Jiaweibugan decoction against diabetic peripheral neuropathy☆
title_fullStr Protective effect of Jiaweibugan decoction against diabetic peripheral neuropathy☆
title_full_unstemmed Protective effect of Jiaweibugan decoction against diabetic peripheral neuropathy☆
title_short Protective effect of Jiaweibugan decoction against diabetic peripheral neuropathy☆
title_sort protective effect of jiaweibugan decoction against diabetic peripheral neuropathy☆
topic Research and Report Article: Traditional Chinese Medicine and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145893/
https://www.ncbi.nlm.nih.gov/pubmed/25206405
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.12.006
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