S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein

Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its...

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Autores principales: Li, Xue, Zhao, Wencong, Yang, Hongqi, Zhang, Junhong, Ma, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Research and Report Article: Neurodegenerative Disease and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145930/
https://www.ncbi.nlm.nih.gov/pubmed/25206568
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.27.009
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author Li, Xue
Zhao, Wencong
Yang, Hongqi
Zhang, Junhong
Ma, Jianjun
author_facet Li, Xue
Zhao, Wencong
Yang, Hongqi
Zhang, Junhong
Ma, Jianjun
author_sort Li, Xue
collection PubMed
description Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear. Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular ho-meostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin restored these responses. The results suggested that S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane, and restored the disturbed cellular homeostasis, thereby exerting a neu-roprotective effect on hippocampal neurons.
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spelling pubmed-41459302014-09-09 S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein Li, Xue Zhao, Wencong Yang, Hongqi Zhang, Junhong Ma, Jianjun Neural Regen Res Research and Report Article: Neurodegenerative Disease and Neural Regeneration Humanin is a potential therapeutic agent for Alzheimer's disease, and its derivative, S14G-humanin, is 1 000-fold stronger in its neuroprotective effect against Alzheimer's disease-relevant insults. Al-though effective, the detailed molecular mechanism through which S14G-humanin exerts its effects remains unclear. Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular ho-meostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin restored these responses. The results suggested that S14G-humanin blocked the effects of amyloid-beta 40 on the neuronal cell membrane, and restored the disturbed cellular homeostasis, thereby exerting a neu-roprotective effect on hippocampal neurons. Medknow Publications & Media Pvt Ltd 2013-09-25 /pmc/articles/PMC4145930/ /pubmed/25206568 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.27.009 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report Article: Neurodegenerative Disease and Neural Regeneration
Li, Xue
Zhao, Wencong
Yang, Hongqi
Zhang, Junhong
Ma, Jianjun
S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein
title S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein
title_full S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein
title_fullStr S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein
title_full_unstemmed S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein
title_short S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein
title_sort s14g-humanin restored cellular homeostasis disturbed by amyloid-beta protein
topic Research and Report Article: Neurodegenerative Disease and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145930/
https://www.ncbi.nlm.nih.gov/pubmed/25206568
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.27.009
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