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PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis
Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145942/ https://www.ncbi.nlm.nih.gov/pubmed/25206651 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.35.004 |
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author | Li, Min Jiang, Jiandong Fu, Bing Chen, Jiechun Xue, Qun Dong, Wanli Gu, Yanzheng Tang, Lingtao Xue, Limin Fang, Qi Wang, Mingyuan Zhang, Xueguang |
author_facet | Li, Min Jiang, Jiandong Fu, Bing Chen, Jiechun Xue, Qun Dong, Wanli Gu, Yanzheng Tang, Lingtao Xue, Limin Fang, Qi Wang, Mingyuan Zhang, Xueguang |
author_sort | Li, Min |
collection | PubMed |
description | Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin oligodendrocyte glycoprotein, complete Freund's adjuvant and Bordetella pertussis toxin into C57BL/6J mice. Experimental allergic encephalomyelitis mice developed disease and showed inflammatory changes in the central nervous system by hematoxylin-eosin staining of spinal cord pathological sections, demyelination by Luxol fast-blue staining and clinical manifestations. The expression of programmed cell death 1 ligand 1 in mice was detected by immunohistochemistry, flow cytometry and western blot analysis. The expression of programmed cell death 1 ligand 1 in the spinal cord and splenocytes of mice was significantly increased compared with normal mice. Our findings suggest the involvement of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis and suggest this should be studied in multiple sclerosis. |
format | Online Article Text |
id | pubmed-4145942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41459422014-09-09 PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis Li, Min Jiang, Jiandong Fu, Bing Chen, Jiechun Xue, Qun Dong, Wanli Gu, Yanzheng Tang, Lingtao Xue, Limin Fang, Qi Wang, Mingyuan Zhang, Xueguang Neural Regen Res Research and Report Article: Neurodegenerative Disease and Neural Regeneration Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin oligodendrocyte glycoprotein, complete Freund's adjuvant and Bordetella pertussis toxin into C57BL/6J mice. Experimental allergic encephalomyelitis mice developed disease and showed inflammatory changes in the central nervous system by hematoxylin-eosin staining of spinal cord pathological sections, demyelination by Luxol fast-blue staining and clinical manifestations. The expression of programmed cell death 1 ligand 1 in mice was detected by immunohistochemistry, flow cytometry and western blot analysis. The expression of programmed cell death 1 ligand 1 in the spinal cord and splenocytes of mice was significantly increased compared with normal mice. Our findings suggest the involvement of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis and suggest this should be studied in multiple sclerosis. Medknow Publications & Media Pvt Ltd 2013-12-15 /pmc/articles/PMC4145942/ /pubmed/25206651 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.35.004 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research and Report Article: Neurodegenerative Disease and Neural Regeneration Li, Min Jiang, Jiandong Fu, Bing Chen, Jiechun Xue, Qun Dong, Wanli Gu, Yanzheng Tang, Lingtao Xue, Limin Fang, Qi Wang, Mingyuan Zhang, Xueguang PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis |
title | PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis |
title_full | PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis |
title_fullStr | PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis |
title_full_unstemmed | PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis |
title_short | PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis |
title_sort | pd-l1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis |
topic | Research and Report Article: Neurodegenerative Disease and Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145942/ https://www.ncbi.nlm.nih.gov/pubmed/25206651 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.35.004 |
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