Cargando…
Neurotoxicity of cancer chemotherapy
There is accumulating clinical evidence that chemotherapeutic agents induce neurological side effects, including memory deficits and mood disorders, in cancer patients who have undergone chemotherapeutic treatments. This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfun...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145960/ https://www.ncbi.nlm.nih.gov/pubmed/25206457 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.17.009 |
_version_ | 1782332250474414080 |
---|---|
author | Yang, Miyoung Moon, Changjong |
author_facet | Yang, Miyoung Moon, Changjong |
author_sort | Yang, Miyoung |
collection | PubMed |
description | There is accumulating clinical evidence that chemotherapeutic agents induce neurological side effects, including memory deficits and mood disorders, in cancer patients who have undergone chemotherapeutic treatments. This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches. These investigations are helpful in determining how best to further explore the causal mechanisms of chemotherapy-induced neurological side effects and in providing direction for the future development of novel optimized chemotherapeutic agents. |
format | Online Article Text |
id | pubmed-4145960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41459602014-09-09 Neurotoxicity of cancer chemotherapy Yang, Miyoung Moon, Changjong Neural Regen Res Neurodegenerative Disease and Neural Regeneration There is accumulating clinical evidence that chemotherapeutic agents induce neurological side effects, including memory deficits and mood disorders, in cancer patients who have undergone chemotherapeutic treatments. This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches. These investigations are helpful in determining how best to further explore the causal mechanisms of chemotherapy-induced neurological side effects and in providing direction for the future development of novel optimized chemotherapeutic agents. Medknow Publications & Media Pvt Ltd 2013-06-15 /pmc/articles/PMC4145960/ /pubmed/25206457 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.17.009 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neurodegenerative Disease and Neural Regeneration Yang, Miyoung Moon, Changjong Neurotoxicity of cancer chemotherapy |
title | Neurotoxicity of cancer chemotherapy |
title_full | Neurotoxicity of cancer chemotherapy |
title_fullStr | Neurotoxicity of cancer chemotherapy |
title_full_unstemmed | Neurotoxicity of cancer chemotherapy |
title_short | Neurotoxicity of cancer chemotherapy |
title_sort | neurotoxicity of cancer chemotherapy |
topic | Neurodegenerative Disease and Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145960/ https://www.ncbi.nlm.nih.gov/pubmed/25206457 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.17.009 |
work_keys_str_mv | AT yangmiyoung neurotoxicityofcancerchemotherapy AT moonchangjong neurotoxicityofcancerchemotherapy |