Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats

Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet f...

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Detalles Bibliográficos
Autores principales: Ge, Jing, Wang, Jun, Xue, Dan, Zhu, Zhengsheng, Chen, Zhenyu, Li, Xiaoqiu, Su, Dongfeng, Du, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Research and Report Article: Basic Research in Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145971/
https://www.ncbi.nlm.nih.gov/pubmed/25206496
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.20.006
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author Ge, Jing
Wang, Jun
Xue, Dan
Zhu, Zhengsheng
Chen, Zhenyu
Li, Xiaoqiu
Su, Dongfeng
Du, Juan
author_facet Ge, Jing
Wang, Jun
Xue, Dan
Zhu, Zhengsheng
Chen, Zhenyu
Li, Xiaoqiu
Su, Dongfeng
Du, Juan
author_sort Ge, Jing
collection PubMed
description Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats.
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spelling pubmed-41459712014-09-09 Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats Ge, Jing Wang, Jun Xue, Dan Zhu, Zhengsheng Chen, Zhenyu Li, Xiaoqiu Su, Dongfeng Du, Juan Neural Regen Res Research and Report Article: Basic Research in Neural Regeneration Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats. Medknow Publications & Media Pvt Ltd 2013-07-15 /pmc/articles/PMC4145971/ /pubmed/25206496 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.20.006 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report Article: Basic Research in Neural Regeneration
Ge, Jing
Wang, Jun
Xue, Dan
Zhu, Zhengsheng
Chen, Zhenyu
Li, Xiaoqiu
Su, Dongfeng
Du, Juan
Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats
title Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats
title_full Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats
title_fullStr Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats
title_full_unstemmed Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats
title_short Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats
title_sort why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats
topic Research and Report Article: Basic Research in Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145971/
https://www.ncbi.nlm.nih.gov/pubmed/25206496
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.20.006
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