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Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats
Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet f...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145971/ https://www.ncbi.nlm.nih.gov/pubmed/25206496 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.20.006 |
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author | Ge, Jing Wang, Jun Xue, Dan Zhu, Zhengsheng Chen, Zhenyu Li, Xiaoqiu Su, Dongfeng Du, Juan |
author_facet | Ge, Jing Wang, Jun Xue, Dan Zhu, Zhengsheng Chen, Zhenyu Li, Xiaoqiu Su, Dongfeng Du, Juan |
author_sort | Ge, Jing |
collection | PubMed |
description | Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats. |
format | Online Article Text |
id | pubmed-4145971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41459712014-09-09 Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats Ge, Jing Wang, Jun Xue, Dan Zhu, Zhengsheng Chen, Zhenyu Li, Xiaoqiu Su, Dongfeng Du, Juan Neural Regen Res Research and Report Article: Basic Research in Neural Regeneration Changes in neurotransmitter levels in the brain play an important role in epilepsy-like attacks after pregnancy-induced preeclampsia-eclampsia. Metabotropic glutamate receptor 1 participates in the onset of lipid metabolism disorder-induced preeclampsia. Pregnant rats were fed with a high-fat diet for 20 days. Thus, these pregnant rats experienced preeclampsia-like syndromes such as tension and proteinuria. Simultaneously, metabotropic glutamate receptor 1 mRNA and protein expressions were upregulated in the rat hippocampus. These findings indicate that increased sion of metabotropic glutamate receptor 1 promotes the occurrence of high-fat diet-induced preeclampsia in pregnant rats. Medknow Publications & Media Pvt Ltd 2013-07-15 /pmc/articles/PMC4145971/ /pubmed/25206496 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.20.006 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research and Report Article: Basic Research in Neural Regeneration Ge, Jing Wang, Jun Xue, Dan Zhu, Zhengsheng Chen, Zhenyu Li, Xiaoqiu Su, Dongfeng Du, Juan Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats |
title | Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats |
title_full | Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats |
title_fullStr | Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats |
title_full_unstemmed | Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats |
title_short | Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats |
title_sort | why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats |
topic | Research and Report Article: Basic Research in Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145971/ https://www.ncbi.nlm.nih.gov/pubmed/25206496 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.20.006 |
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