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Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage

Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis...

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Detalles Bibliográficos
Autores principales: Chen, Gang, Hu, Tong, Li, Qi, Li, Jianke, Jia, Yang, Wang, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145993/
https://www.ncbi.nlm.nih.gov/pubmed/25206580
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.29.001
Descripción
Sumario:Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that synaptosomal-associated protein-25 expression in the temporal lobe, hippocampus, and cerebellum significantly lower at days 1 and 3 following subarachnoid morrhage. Our findings indicate that synaptosomal-associated protein-25 expression was down-regulated in the rat brain after subarachnoid hemorrhage.