Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage

Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis...

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Autores principales: Chen, Gang, Hu, Tong, Li, Qi, Li, Jianke, Jia, Yang, Wang, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Research and Report Article: Brain Injury and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145993/
https://www.ncbi.nlm.nih.gov/pubmed/25206580
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.29.001
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author Chen, Gang
Hu, Tong
Li, Qi
Li, Jianke
Jia, Yang
Wang, Zhong
author_facet Chen, Gang
Hu, Tong
Li, Qi
Li, Jianke
Jia, Yang
Wang, Zhong
author_sort Chen, Gang
collection PubMed
description Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that synaptosomal-associated protein-25 expression in the temporal lobe, hippocampus, and cerebellum significantly lower at days 1 and 3 following subarachnoid morrhage. Our findings indicate that synaptosomal-associated protein-25 expression was down-regulated in the rat brain after subarachnoid hemorrhage.
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spelling pubmed-41459932014-09-09 Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage Chen, Gang Hu, Tong Li, Qi Li, Jianke Jia, Yang Wang, Zhong Neural Regen Res Research and Report Article: Brain Injury and Neural Regeneration Synaptosomal-associated protein-25 is an important factor for synaptic functions and cognition. In this study, subarachnoid hemorrhage models with spatial learning disorder were established through a blood injection into the chiasmatic cistern. Immunohistochemical staining and western blot analysis results showed that synaptosomal-associated protein-25 expression in the temporal lobe, hippocampus, and cerebellum significantly lower at days 1 and 3 following subarachnoid morrhage. Our findings indicate that synaptosomal-associated protein-25 expression was down-regulated in the rat brain after subarachnoid hemorrhage. Medknow Publications & Media Pvt Ltd 2013-10-15 /pmc/articles/PMC4145993/ /pubmed/25206580 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.29.001 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report Article: Brain Injury and Neural Regeneration
Chen, Gang
Hu, Tong
Li, Qi
Li, Jianke
Jia, Yang
Wang, Zhong
Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage
title Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage
title_full Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage
title_fullStr Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage
title_full_unstemmed Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage
title_short Expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage
title_sort expression of synaptosomal-associated protein-25 in the rat brain after subarachnoid hemorrhage
topic Research and Report Article: Brain Injury and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145993/
https://www.ncbi.nlm.nih.gov/pubmed/25206580
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.29.001
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