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Mechanism of Erhuang capsule for treatment of multiple sclerosis
Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146050/ https://www.ncbi.nlm.nih.gov/pubmed/25206695 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.005 |
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author | Li, Kangning Fan, Yongping Yang, Tao Wang, Lei |
author_facet | Li, Kangning Fan, Yongping Yang, Tao Wang, Lei |
author_sort | Li, Kangning |
collection | PubMed |
description | Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation. |
format | Online Article Text |
id | pubmed-4146050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41460502014-09-09 Mechanism of Erhuang capsule for treatment of multiple sclerosis Li, Kangning Fan, Yongping Yang, Tao Wang, Lei Neural Regen Res Traditional Chinese Medicine and Neural Regeneration Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation. Medknow Publications & Media Pvt Ltd 2013-02-25 /pmc/articles/PMC4146050/ /pubmed/25206695 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Traditional Chinese Medicine and Neural Regeneration Li, Kangning Fan, Yongping Yang, Tao Wang, Lei Mechanism of Erhuang capsule for treatment of multiple sclerosis |
title | Mechanism of Erhuang capsule for treatment of multiple sclerosis |
title_full | Mechanism of Erhuang capsule for treatment of multiple sclerosis |
title_fullStr | Mechanism of Erhuang capsule for treatment of multiple sclerosis |
title_full_unstemmed | Mechanism of Erhuang capsule for treatment of multiple sclerosis |
title_short | Mechanism of Erhuang capsule for treatment of multiple sclerosis |
title_sort | mechanism of erhuang capsule for treatment of multiple sclerosis |
topic | Traditional Chinese Medicine and Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146050/ https://www.ncbi.nlm.nih.gov/pubmed/25206695 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.005 |
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