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Mechanism of Erhuang capsule for treatment of multiple sclerosis

Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In...

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Autores principales: Li, Kangning, Fan, Yongping, Yang, Tao, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146050/
https://www.ncbi.nlm.nih.gov/pubmed/25206695
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.005
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author Li, Kangning
Fan, Yongping
Yang, Tao
Wang, Lei
author_facet Li, Kangning
Fan, Yongping
Yang, Tao
Wang, Lei
author_sort Li, Kangning
collection PubMed
description Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation.
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spelling pubmed-41460502014-09-09 Mechanism of Erhuang capsule for treatment of multiple sclerosis Li, Kangning Fan, Yongping Yang, Tao Wang, Lei Neural Regen Res Traditional Chinese Medicine and Neural Regeneration Erhuang capsule, a typical formula based on traditional Chinese medicine theory, is widely used to ameliorate multiple sclerosis, inflammation and side effects of glucocorticoid treatment. Oligodendrocyte precursor cells are neural stem cells that are important for myelin repair and regeneration. In the present study, Erhuang capsule effectively improved clinical symptoms and neurological function scores, reduced mortality and promoted recovery of neurological functions of mice with experimental autoimmune encephalomyelitis. The mechanism of action involved significant increases in oligodendrocyte precursor cell proliferation in specific regions of the brain and spinal cord, increased oligodendrocyte lineage gene 2 expression and enhanced oligodendrocyte precursor cell differentiation. Medknow Publications & Media Pvt Ltd 2013-02-25 /pmc/articles/PMC4146050/ /pubmed/25206695 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Traditional Chinese Medicine and Neural Regeneration
Li, Kangning
Fan, Yongping
Yang, Tao
Wang, Lei
Mechanism of Erhuang capsule for treatment of multiple sclerosis
title Mechanism of Erhuang capsule for treatment of multiple sclerosis
title_full Mechanism of Erhuang capsule for treatment of multiple sclerosis
title_fullStr Mechanism of Erhuang capsule for treatment of multiple sclerosis
title_full_unstemmed Mechanism of Erhuang capsule for treatment of multiple sclerosis
title_short Mechanism of Erhuang capsule for treatment of multiple sclerosis
title_sort mechanism of erhuang capsule for treatment of multiple sclerosis
topic Traditional Chinese Medicine and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146050/
https://www.ncbi.nlm.nih.gov/pubmed/25206695
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.005
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