Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats
Chronic stress models, established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone, once per day, were given a daily oral feeding of 50 mg/kg baicalin. The study was an attempt to observe the effect of baicalin on neurogenesis in chronically stressed r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146053/ https://www.ncbi.nlm.nih.gov/pubmed/25206692 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.002 |
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author | Jiang, Xinghua Xu, Junmei Zou, Dingquan Yang, Lin Wang, Yaping |
author_facet | Jiang, Xinghua Xu, Junmei Zou, Dingquan Yang, Lin Wang, Yaping |
author_sort | Jiang, Xinghua |
collection | PubMed |
description | Chronic stress models, established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone, once per day, were given a daily oral feeding of 50 mg/kg baicalin. The study was an attempt to observe the effect of baicalin on neurogenesis in chronically stressed rats. Results showed that subcutaneous injection of corticosterone significantly decreased the total number of doublecortin-positive neurons in the hippocampus. The reduced cell number caused by corticosterone was mainly due to the decrease of class II doublecortin-positive neurons, but the class I doublecortin-positive neurons were unaffected. Baicalin treatment increased the number of both class I and class II doublecortin-positive neurons. In addition, doublecortin-positive neurons showed less complexity in dendritic morphology after corticosterone injection, and this change was totally reversed by baicalin treatment. These findings suggest that baicalin exhibits a beneficial effect on adult neurogenesis. |
format | Online Article Text |
id | pubmed-4146053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41460532014-09-09 Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats Jiang, Xinghua Xu, Junmei Zou, Dingquan Yang, Lin Wang, Yaping Neural Regen Res Traditional Chinese Medicine and Neural Regeneration Chronic stress models, established in adult Sprague-Dawley rats through a 14-day subcutaneous injection of 40 mg/kg corticosterone, once per day, were given a daily oral feeding of 50 mg/kg baicalin. The study was an attempt to observe the effect of baicalin on neurogenesis in chronically stressed rats. Results showed that subcutaneous injection of corticosterone significantly decreased the total number of doublecortin-positive neurons in the hippocampus. The reduced cell number caused by corticosterone was mainly due to the decrease of class II doublecortin-positive neurons, but the class I doublecortin-positive neurons were unaffected. Baicalin treatment increased the number of both class I and class II doublecortin-positive neurons. In addition, doublecortin-positive neurons showed less complexity in dendritic morphology after corticosterone injection, and this change was totally reversed by baicalin treatment. These findings suggest that baicalin exhibits a beneficial effect on adult neurogenesis. Medknow Publications & Media Pvt Ltd 2013-02-25 /pmc/articles/PMC4146053/ /pubmed/25206692 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.002 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Traditional Chinese Medicine and Neural Regeneration Jiang, Xinghua Xu, Junmei Zou, Dingquan Yang, Lin Wang, Yaping Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats |
title | Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats |
title_full | Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats |
title_fullStr | Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats |
title_full_unstemmed | Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats |
title_short | Baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats |
title_sort | baicalin influences the dendritic morphology of newborn neurons in the hippocampus of chronically stressed rats |
topic | Traditional Chinese Medicine and Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146053/ https://www.ncbi.nlm.nih.gov/pubmed/25206692 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.002 |
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