Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats

Acupuncture for the treatment of Parkinson's disease has a precise clinical outcome. This study investigated the effect of electroacupuncture at Fengfu (GV16) and Taichong (LR3) acupoints in rat models of Parkinson's disease induced by subcutaneous injection of rotenone into rat neck and b...

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Autores principales: Wang, Shuju, Fang, Jianqiao, Ma, Jun, Wang, Yanchun, Liang, Shaorong, Zhou, Dan, Sun, Guojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acupuncture and Moxibustion and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146059/
https://www.ncbi.nlm.nih.gov/pubmed/25206697
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.007
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author Wang, Shuju
Fang, Jianqiao
Ma, Jun
Wang, Yanchun
Liang, Shaorong
Zhou, Dan
Sun, Guojie
author_facet Wang, Shuju
Fang, Jianqiao
Ma, Jun
Wang, Yanchun
Liang, Shaorong
Zhou, Dan
Sun, Guojie
author_sort Wang, Shuju
collection PubMed
description Acupuncture for the treatment of Parkinson's disease has a precise clinical outcome. This study investigated the effect of electroacupuncture at Fengfu (GV16) and Taichong (LR3) acupoints in rat models of Parkinson's disease induced by subcutaneous injection of rotenone into rat neck and back. Reverse transcription-PCR demonstrated that brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression was significantly increased in the substantia nigra of rat models of Parkinson's disease, and that abnormal behavior of rats was significantly improved following electroacupuncture treatment. These results indicated that electroacupuncture treatment upregulated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression in the substantia nigra of rat models of Parkinson's disease. Thus, electroacupuncture may be useful in the treatment of Parkinson's disease.
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spelling pubmed-41460592014-09-09 Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats Wang, Shuju Fang, Jianqiao Ma, Jun Wang, Yanchun Liang, Shaorong Zhou, Dan Sun, Guojie Neural Regen Res Acupuncture and Moxibustion and Neural Regeneration Acupuncture for the treatment of Parkinson's disease has a precise clinical outcome. This study investigated the effect of electroacupuncture at Fengfu (GV16) and Taichong (LR3) acupoints in rat models of Parkinson's disease induced by subcutaneous injection of rotenone into rat neck and back. Reverse transcription-PCR demonstrated that brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression was significantly increased in the substantia nigra of rat models of Parkinson's disease, and that abnormal behavior of rats was significantly improved following electroacupuncture treatment. These results indicated that electroacupuncture treatment upregulated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression in the substantia nigra of rat models of Parkinson's disease. Thus, electroacupuncture may be useful in the treatment of Parkinson's disease. Medknow Publications & Media Pvt Ltd 2013-02-25 /pmc/articles/PMC4146059/ /pubmed/25206697 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.007 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Acupuncture and Moxibustion and Neural Regeneration
Wang, Shuju
Fang, Jianqiao
Ma, Jun
Wang, Yanchun
Liang, Shaorong
Zhou, Dan
Sun, Guojie
Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats
title Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats
title_full Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats
title_fullStr Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats
title_full_unstemmed Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats
title_short Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats
title_sort electroacupuncture-regulated neurotrophic factor mrna expression in the substantia nigra of parkinson's disease rats
topic Acupuncture and Moxibustion and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146059/
https://www.ncbi.nlm.nih.gov/pubmed/25206697
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.06.007
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