Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment

The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells injured by 400 μmol/L corticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing se...

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Autores principales: Chen, Liping, Sun, Zhigao, Wang, Fawei, Xu, Chengyong, Geng, Miao, Chen, Hongyan, Duan, Dongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Research and Report Article: Traditional Chinese Medicine and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146065/
https://www.ncbi.nlm.nih.gov/pubmed/25206514
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.22.005
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author Chen, Liping
Sun, Zhigao
Wang, Fawei
Xu, Chengyong
Geng, Miao
Chen, Hongyan
Duan, Dongmei
author_facet Chen, Liping
Sun, Zhigao
Wang, Fawei
Xu, Chengyong
Geng, Miao
Chen, Hongyan
Duan, Dongmei
author_sort Chen, Liping
collection PubMed
description The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells injured by 400 μmol/L corticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high-dose (30 μg/mL) Shuyusan-containing serum was more remarkable. Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor. Moreover, high-dose Shuyusan-containing serum has a protective effect on high-dose corticosterone-induced impairment.
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spelling pubmed-41460652014-09-09 Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment Chen, Liping Sun, Zhigao Wang, Fawei Xu, Chengyong Geng, Miao Chen, Hongyan Duan, Dongmei Neural Regen Res Research and Report Article: Traditional Chinese Medicine and Neural Regeneration The Chinese herb Shuyusan, whose main constituent is jasminoidin, has been shown to protect SH-SY5Y cells against corticosterone-induced damage. SH-SY5Y cells injured by 400 μmol/L corticosterone were treated with 5 and 30 μg/mL Shuyusan-containing serum. Results revealed that Shuyusan-containing serum elevated the survival rate of SH-SY5Y cells, reduced Bax expression, increased Bcl-2 expression, markedly elevated brain-derived neurotrophic factor mRNA expression, and blocked cell apoptosis. Moreover, the effect of high-dose (30 μg/mL) Shuyusan-containing serum was more remarkable. Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor. Moreover, high-dose Shuyusan-containing serum has a protective effect on high-dose corticosterone-induced impairment. Medknow Publications & Media Pvt Ltd 2013-08-05 /pmc/articles/PMC4146065/ /pubmed/25206514 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.22.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report Article: Traditional Chinese Medicine and Neural Regeneration
Chen, Liping
Sun, Zhigao
Wang, Fawei
Xu, Chengyong
Geng, Miao
Chen, Hongyan
Duan, Dongmei
Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment
title Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment
title_full Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment
title_fullStr Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment
title_full_unstemmed Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment
title_short Shuyusan-containing serum protects SH-SY5Y cells against corticosterone-induced impairment
title_sort shuyusan-containing serum protects sh-sy5y cells against corticosterone-induced impairment
topic Research and Report Article: Traditional Chinese Medicine and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146065/
https://www.ncbi.nlm.nih.gov/pubmed/25206514
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.22.005
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