Electroacupuncture at He-Mu points reduces P2X(4) receptor expression in visceral hypersensitivity

Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats. Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome. Results showed that abdominal withdrawal reflex scores not...

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Autores principales: Guo, Xinxin, Chen, Jifei, Lu, Yuan, Wu, Luyi, Weng, Zhijun, Yang, Ling, Xin, Yuhu, Lin, Xianming, Liang, Yi, Fang, Jianqiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Research and Report Article: Acupuncture and Moxibustion and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146068/
https://www.ncbi.nlm.nih.gov/pubmed/25206515
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.22.006
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author Guo, Xinxin
Chen, Jifei
Lu, Yuan
Wu, Luyi
Weng, Zhijun
Yang, Ling
Xin, Yuhu
Lin, Xianming
Liang, Yi
Fang, Jianqiao
author_facet Guo, Xinxin
Chen, Jifei
Lu, Yuan
Wu, Luyi
Weng, Zhijun
Yang, Ling
Xin, Yuhu
Lin, Xianming
Liang, Yi
Fang, Jianqiao
author_sort Guo, Xinxin
collection PubMed
description Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats. Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome. Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X(4) receptor immureactivity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X(4) receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X(4) receptor immunoreactivity in the colon and spinal cord.
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spelling pubmed-41460682014-09-09 Electroacupuncture at He-Mu points reduces P2X(4) receptor expression in visceral hypersensitivity Guo, Xinxin Chen, Jifei Lu, Yuan Wu, Luyi Weng, Zhijun Yang, Ling Xin, Yuhu Lin, Xianming Liang, Yi Fang, Jianqiao Neural Regen Res Research and Report Article: Acupuncture and Moxibustion and Neural Regeneration Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) was reported to improve visceral hypersensitivity in rats. Colorectal distension was utilized to generate a rat model of chronic visceral hypersensitivity in irritable bowel syndrome. Results showed that abdominal withdrawal reflex scores noticeably increased after model establishment. Simultaneously, P2X(4) receptor immureactivity significantly increased in the colon and spinal cord. Electroacupuncture and pinaverium bromide therapy both markedly decreased abdominal withdrawal reflex scores in rats with visceral hypersensitivity, and significantly decreased P2X(4) receptor immunoreactivity in the colon and spinal cord. These data suggest that electroacupuncture treatment can improve visceral hypersensitivity in rats with irritable bowel syndrome by diminishing P2X(4) receptor immunoreactivity in the colon and spinal cord. Medknow Publications & Media Pvt Ltd 2013-08-05 /pmc/articles/PMC4146068/ /pubmed/25206515 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.22.006 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report Article: Acupuncture and Moxibustion and Neural Regeneration
Guo, Xinxin
Chen, Jifei
Lu, Yuan
Wu, Luyi
Weng, Zhijun
Yang, Ling
Xin, Yuhu
Lin, Xianming
Liang, Yi
Fang, Jianqiao
Electroacupuncture at He-Mu points reduces P2X(4) receptor expression in visceral hypersensitivity
title Electroacupuncture at He-Mu points reduces P2X(4) receptor expression in visceral hypersensitivity
title_full Electroacupuncture at He-Mu points reduces P2X(4) receptor expression in visceral hypersensitivity
title_fullStr Electroacupuncture at He-Mu points reduces P2X(4) receptor expression in visceral hypersensitivity
title_full_unstemmed Electroacupuncture at He-Mu points reduces P2X(4) receptor expression in visceral hypersensitivity
title_short Electroacupuncture at He-Mu points reduces P2X(4) receptor expression in visceral hypersensitivity
title_sort electroacupuncture at he-mu points reduces p2x(4) receptor expression in visceral hypersensitivity
topic Research and Report Article: Acupuncture and Moxibustion and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146068/
https://www.ncbi.nlm.nih.gov/pubmed/25206515
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.22.006
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