Role of calbindin-D28K in estrogen treatment for Parkinson's disease★

Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 17β estradiol injection into th...

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Detalles Bibliográficos
Autores principales: Wang, Chunhua, Jiang, Chao, Yuan, Honghua, Xiao, Chenghua, Gao, Dianshuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Neurodegenerative Disease and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146078/
https://www.ncbi.nlm.nih.gov/pubmed/25206716
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.08.004
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author Wang, Chunhua
Jiang, Chao
Yuan, Honghua
Xiao, Chenghua
Gao, Dianshuai
author_facet Wang, Chunhua
Jiang, Chao
Yuan, Honghua
Xiao, Chenghua
Gao, Dianshuai
author_sort Wang, Chunhua
collection PubMed
description Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 17β estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson's disease.
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spelling pubmed-41460782014-09-09 Role of calbindin-D28K in estrogen treatment for Parkinson's disease★ Wang, Chunhua Jiang, Chao Yuan, Honghua Xiao, Chenghua Gao, Dianshuai Neural Regen Res Neurodegenerative Disease and Neural Regeneration Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 17β estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson's disease. Medknow Publications & Media Pvt Ltd 2013-03-15 /pmc/articles/PMC4146078/ /pubmed/25206716 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.08.004 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Neurodegenerative Disease and Neural Regeneration
Wang, Chunhua
Jiang, Chao
Yuan, Honghua
Xiao, Chenghua
Gao, Dianshuai
Role of calbindin-D28K in estrogen treatment for Parkinson's disease★
title Role of calbindin-D28K in estrogen treatment for Parkinson's disease★
title_full Role of calbindin-D28K in estrogen treatment for Parkinson's disease★
title_fullStr Role of calbindin-D28K in estrogen treatment for Parkinson's disease★
title_full_unstemmed Role of calbindin-D28K in estrogen treatment for Parkinson's disease★
title_short Role of calbindin-D28K in estrogen treatment for Parkinson's disease★
title_sort role of calbindin-d28k in estrogen treatment for parkinson's disease★
topic Neurodegenerative Disease and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146078/
https://www.ncbi.nlm.nih.gov/pubmed/25206716
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.08.004
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AT xiaochenghua roleofcalbindind28kinestrogentreatmentforparkinsonsdisease
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