Electroacupuncture diminishes P2X(2) and P2X(3) purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity★

Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X(2) and P2X(3) receptor expression in dorsal root ganglia...

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Detalles Bibliográficos
Autores principales: Weng, Zhijun, Wu, Luyi, Lu, Yuan, Wang, Lidong, Tan, Linying, Dong, Ming, Xin, Yuhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acupuncture and Moxibustion and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146084/
https://www.ncbi.nlm.nih.gov/pubmed/25206727
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.09.004
Descripción
Sumario:Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X(2) and P2X(3) receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X(2) and P2X(3) receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X(2) and P2X(3) receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X(2) and P2X(3) receptor expression in dorsal root ganglia.

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