Electroacupuncture diminishes P2X(2) and P2X(3) purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity★

Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X(2) and P2X(3) receptor expression in dorsal root ganglia...

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Autores principales: Weng, Zhijun, Wu, Luyi, Lu, Yuan, Wang, Lidong, Tan, Linying, Dong, Ming, Xin, Yuhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acupuncture and Moxibustion and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146084/
https://www.ncbi.nlm.nih.gov/pubmed/25206727
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.09.004
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author Weng, Zhijun
Wu, Luyi
Lu, Yuan
Wang, Lidong
Tan, Linying
Dong, Ming
Xin, Yuhu
author_facet Weng, Zhijun
Wu, Luyi
Lu, Yuan
Wang, Lidong
Tan, Linying
Dong, Ming
Xin, Yuhu
author_sort Weng, Zhijun
collection PubMed
description Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X(2) and P2X(3) receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X(2) and P2X(3) receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X(2) and P2X(3) receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X(2) and P2X(3) receptor expression in dorsal root ganglia.
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spelling pubmed-41460842014-09-09 Electroacupuncture diminishes P2X(2) and P2X(3) purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity★ Weng, Zhijun Wu, Luyi Lu, Yuan Wang, Lidong Tan, Linying Dong, Ming Xin, Yuhu Neural Regen Res Acupuncture and Moxibustion and Neural Regeneration Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X(2) and P2X(3) receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity. Results demonstrated that abdominal withdrawal reflex scores obviously increased following establishment of the model, indicating visceral hypersensitivity. Simultaneously, P2X(2) and P2X(3) receptor expression increased in dorsal root ganglia. After bilateral electroacupuncture at Shangjuxu and Tianshu, abdominal withdrawal reflex scores and P2X(2) and P2X(3) receptor expression decreased in rats with visceral hypersensitivity. These results indicated that electroacupuncture treatment improved visceral hypersensitivity in rats with irritable bowel syndrome by reducing P2X(2) and P2X(3) receptor expression in dorsal root ganglia. Medknow Publications & Media Pvt Ltd 2013-03-25 /pmc/articles/PMC4146084/ /pubmed/25206727 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.09.004 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Acupuncture and Moxibustion and Neural Regeneration
Weng, Zhijun
Wu, Luyi
Lu, Yuan
Wang, Lidong
Tan, Linying
Dong, Ming
Xin, Yuhu
Electroacupuncture diminishes P2X(2) and P2X(3) purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity★
title Electroacupuncture diminishes P2X(2) and P2X(3) purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity★
title_full Electroacupuncture diminishes P2X(2) and P2X(3) purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity★
title_fullStr Electroacupuncture diminishes P2X(2) and P2X(3) purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity★
title_full_unstemmed Electroacupuncture diminishes P2X(2) and P2X(3) purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity★
title_short Electroacupuncture diminishes P2X(2) and P2X(3) purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity★
title_sort electroacupuncture diminishes p2x(2) and p2x(3) purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity★
topic Acupuncture and Moxibustion and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146084/
https://www.ncbi.nlm.nih.gov/pubmed/25206727
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.09.004
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