Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder☆

The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway plays an important role in the mechanism of action of antidepressant drugs and has dominated recent studies on the pathogenesis of depression. In the present...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Hongyan, Zhang, Yingquan, Qiao, Mingqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Basic Research in Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146087/
https://www.ncbi.nlm.nih.gov/pubmed/25206732
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.09.009
_version_ 1782332280140726272
author Wang, Hongyan
Zhang, Yingquan
Qiao, Mingqi
author_facet Wang, Hongyan
Zhang, Yingquan
Qiao, Mingqi
author_sort Wang, Hongyan
collection PubMed
description The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway plays an important role in the mechanism of action of antidepressant drugs and has dominated recent studies on the pathogenesis of depression. In the present review we summarize the known roles of extracellular signal-regulated kinase, cAMP response element-binding protein and brain-derived neurotrophic factor in the pathogenesis of depression and in the mechanism of action of antidepressant medicines. The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor pathway has potential to be used as a biological index to help diagnose depression, and as such it is considered as an important new target in the treatment of depression.
format Online
Article
Text
id pubmed-4146087
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-41460872014-09-09 Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder☆ Wang, Hongyan Zhang, Yingquan Qiao, Mingqi Neural Regen Res Basic Research in Neural Regeneration The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway plays an important role in the mechanism of action of antidepressant drugs and has dominated recent studies on the pathogenesis of depression. In the present review we summarize the known roles of extracellular signal-regulated kinase, cAMP response element-binding protein and brain-derived neurotrophic factor in the pathogenesis of depression and in the mechanism of action of antidepressant medicines. The extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor pathway has potential to be used as a biological index to help diagnose depression, and as such it is considered as an important new target in the treatment of depression. Medknow Publications & Media Pvt Ltd 2013-03-25 /pmc/articles/PMC4146087/ /pubmed/25206732 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.09.009 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic Research in Neural Regeneration
Wang, Hongyan
Zhang, Yingquan
Qiao, Mingqi
Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder☆
title Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder☆
title_full Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder☆
title_fullStr Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder☆
title_full_unstemmed Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder☆
title_short Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder☆
title_sort mechanisms of extracellular signal-regulated kinase/camp response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder☆
topic Basic Research in Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146087/
https://www.ncbi.nlm.nih.gov/pubmed/25206732
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.09.009
work_keys_str_mv AT wanghongyan mechanismsofextracellularsignalregulatedkinasecampresponseelementbindingproteinbrainderivedneurotrophicfactorsignaltransductionpathwayindepressivedisorder
AT zhangyingquan mechanismsofextracellularsignalregulatedkinasecampresponseelementbindingproteinbrainderivedneurotrophicfactorsignaltransductionpathwayindepressivedisorder
AT qiaomingqi mechanismsofextracellularsignalregulatedkinasecampresponseelementbindingproteinbrainderivedneurotrophicfactorsignaltransductionpathwayindepressivedisorder

Ejemplares similares