Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats

Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion i...

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Autores principales: Ji, Xiangyu, Zhang, Li’na, Liu, Ran, Liu, Yingzhi, Song, Jianfang, Dong, He, Jia, Yanfang, Zhou, Zangong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Research and Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146093/
https://www.ncbi.nlm.nih.gov/pubmed/25206771
http://dx.doi.org/10.4103/1673-5374.135314
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author Ji, Xiangyu
Zhang, Li’na
Liu, Ran
Liu, Yingzhi
Song, Jianfang
Dong, He
Jia, Yanfang
Zhou, Zangong
author_facet Ji, Xiangyu
Zhang, Li’na
Liu, Ran
Liu, Yingzhi
Song, Jianfang
Dong, He
Jia, Yanfang
Zhou, Zangong
author_sort Ji, Xiangyu
collection PubMed
description Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats using a comparative proteomics strategy. Our experimental results show that the aged rat brain is sensitive to ischemia-reperfusion injury and that transient ischemia led to cell apoptosis in the hippocampus and changes in memory and cognition of aged rats. Differential proteomics analysis suggested that this phenomenon may be mediated by mitochondrial proteins associated with energy metabolism and apoptosis in aged rats. This study provides potential drug targets for the treatment of transient cerebral ischemia-reperfusion injury.
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spelling pubmed-41460932014-09-09 Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats Ji, Xiangyu Zhang, Li’na Liu, Ran Liu, Yingzhi Song, Jianfang Dong, He Jia, Yanfang Zhou, Zangong Neural Regen Res Research and Report Mitochondria play an important role in neuronal apoptosis caused by cerebral ischemia, and the role is mediated by the expression of mitochondrial proteins. This study investigated the involvement of mitochondrial proteins in hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats using a comparative proteomics strategy. Our experimental results show that the aged rat brain is sensitive to ischemia-reperfusion injury and that transient ischemia led to cell apoptosis in the hippocampus and changes in memory and cognition of aged rats. Differential proteomics analysis suggested that this phenomenon may be mediated by mitochondrial proteins associated with energy metabolism and apoptosis in aged rats. This study provides potential drug targets for the treatment of transient cerebral ischemia-reperfusion injury. Medknow Publications & Media Pvt Ltd 2014-06-01 /pmc/articles/PMC4146093/ /pubmed/25206771 http://dx.doi.org/10.4103/1673-5374.135314 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report
Ji, Xiangyu
Zhang, Li’na
Liu, Ran
Liu, Yingzhi
Song, Jianfang
Dong, He
Jia, Yanfang
Zhou, Zangong
Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats
title Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats
title_full Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats
title_fullStr Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats
title_full_unstemmed Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats
title_short Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats
title_sort potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats
topic Research and Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146093/
https://www.ncbi.nlm.nih.gov/pubmed/25206771
http://dx.doi.org/10.4103/1673-5374.135314
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