Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia

The transcription factor early growth response protein 3 (EGR3) is involved in schizophrenia. We developed a putative rat model of schizophrenia by transfecting lentiviral particles carrying the Egr3 gene into bilateral hippocampal dentate gyrus. We assessed spatial working memory using the Morris w...

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Autores principales: Ma, Guolin, Song, Tianbin, Chen, Min, Fu, Yuan, Xu, Yong, Ma, Ensen, Wang, Wu, Du, Jiang, Huang, Mingxiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Research and Report Article: Evaluation in Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146111/
https://www.ncbi.nlm.nih.gov/pubmed/25206551
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.26.002
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author Ma, Guolin
Song, Tianbin
Chen, Min
Fu, Yuan
Xu, Yong
Ma, Ensen
Wang, Wu
Du, Jiang
Huang, Mingxiong
author_facet Ma, Guolin
Song, Tianbin
Chen, Min
Fu, Yuan
Xu, Yong
Ma, Ensen
Wang, Wu
Du, Jiang
Huang, Mingxiong
author_sort Ma, Guolin
collection PubMed
description The transcription factor early growth response protein 3 (EGR3) is involved in schizophrenia. We developed a putative rat model of schizophrenia by transfecting lentiviral particles carrying the Egr3 gene into bilateral hippocampal dentate gyrus. We assessed spatial working memory using the Morris water maze test, and neuronal metabolite levels in bilateral hippocampus and thalamus were determined by 3.0 T proton magnetic resonance spectroscopy. Choline content was significantly greater in the hippocampus after transfection, while N-acetylaspartate and the ratio of N-acetylaspartate to creatine/phosphocreatine in the thalamus were lower than in controls. This study is the first to report evaluation of brain metabolites using 3.0 T proton magnetic resonance spectroscopy in rats transfected with Egr3, and reveals metabolic abnormalities in the hippocampus and thalamus in this putative model of schizophrenia.
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spelling pubmed-41461112014-09-09 Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia Ma, Guolin Song, Tianbin Chen, Min Fu, Yuan Xu, Yong Ma, Ensen Wang, Wu Du, Jiang Huang, Mingxiong Neural Regen Res Research and Report Article: Evaluation in Neural Regeneration The transcription factor early growth response protein 3 (EGR3) is involved in schizophrenia. We developed a putative rat model of schizophrenia by transfecting lentiviral particles carrying the Egr3 gene into bilateral hippocampal dentate gyrus. We assessed spatial working memory using the Morris water maze test, and neuronal metabolite levels in bilateral hippocampus and thalamus were determined by 3.0 T proton magnetic resonance spectroscopy. Choline content was significantly greater in the hippocampus after transfection, while N-acetylaspartate and the ratio of N-acetylaspartate to creatine/phosphocreatine in the thalamus were lower than in controls. This study is the first to report evaluation of brain metabolites using 3.0 T proton magnetic resonance spectroscopy in rats transfected with Egr3, and reveals metabolic abnormalities in the hippocampus and thalamus in this putative model of schizophrenia. Medknow Publications & Media Pvt Ltd 2013-09-15 /pmc/articles/PMC4146111/ /pubmed/25206551 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.26.002 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report Article: Evaluation in Neural Regeneration
Ma, Guolin
Song, Tianbin
Chen, Min
Fu, Yuan
Xu, Yong
Ma, Ensen
Wang, Wu
Du, Jiang
Huang, Mingxiong
Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
title Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
title_full Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
title_fullStr Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
title_full_unstemmed Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
title_short Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
title_sort hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
topic Research and Report Article: Evaluation in Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146111/
https://www.ncbi.nlm.nih.gov/pubmed/25206551
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.26.002
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