Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: Electrophysiological changes and long-term efficacy

Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were...

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Autores principales: Yao, Liqing, He, Chuan, Zhao, Ying, Wang, Jirong, Tang, Mei, Li, Jun, Wu, Ying, Ao, Lijuan, Hu, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Spinal Cord Injury and Neural Regeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146127/
https://www.ncbi.nlm.nih.gov/pubmed/25206680
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.05.002
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author Yao, Liqing
He, Chuan
Zhao, Ying
Wang, Jirong
Tang, Mei
Li, Jun
Wu, Ying
Ao, Lijuan
Hu, Xiang
author_facet Yao, Liqing
He, Chuan
Zhao, Ying
Wang, Jirong
Tang, Mei
Li, Jun
Wu, Ying
Ao, Lijuan
Hu, Xiang
author_sort Yao, Liqing
collection PubMed
description Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbilical cord blood stem cells via intravenous and intrathecal injection. The follow-up period was 12 months after transplantation. Results found that autonomic nerve functions were restored and the latent period of somatosensory evoked potentials was reduced. There were no severe adverse reactions in patients following stem cell transplantation. These experimental findings suggest that the transplantation of human umbilical cord blood stem cells is a safe and effective treatment for patients with traumatic spinal cord injury.
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spelling pubmed-41461272014-09-09 Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: Electrophysiological changes and long-term efficacy Yao, Liqing He, Chuan Zhao, Ying Wang, Jirong Tang, Mei Li, Jun Wu, Ying Ao, Lijuan Hu, Xiang Neural Regen Res Spinal Cord Injury and Neural Regeneration Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbilical cord blood stem cells via intravenous and intrathecal injection. The follow-up period was 12 months after transplantation. Results found that autonomic nerve functions were restored and the latent period of somatosensory evoked potentials was reduced. There were no severe adverse reactions in patients following stem cell transplantation. These experimental findings suggest that the transplantation of human umbilical cord blood stem cells is a safe and effective treatment for patients with traumatic spinal cord injury. Medknow Publications & Media Pvt Ltd 2013-02-15 /pmc/articles/PMC4146127/ /pubmed/25206680 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.05.002 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Spinal Cord Injury and Neural Regeneration
Yao, Liqing
He, Chuan
Zhao, Ying
Wang, Jirong
Tang, Mei
Li, Jun
Wu, Ying
Ao, Lijuan
Hu, Xiang
Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: Electrophysiological changes and long-term efficacy
title Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: Electrophysiological changes and long-term efficacy
title_full Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: Electrophysiological changes and long-term efficacy
title_fullStr Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: Electrophysiological changes and long-term efficacy
title_full_unstemmed Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: Electrophysiological changes and long-term efficacy
title_short Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: Electrophysiological changes and long-term efficacy
title_sort human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury: electrophysiological changes and long-term efficacy
topic Spinal Cord Injury and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146127/
https://www.ncbi.nlm.nih.gov/pubmed/25206680
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.05.002
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