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Brain imaging of mild cognitive impairment and Alzheimer's disease
The rapidly increasing prevalence of cognitive impairment and Alzheimer's disease has the potential to create a major worldwide healthcare crisis. Structural MRI studies in patients with Alzheimer's disease and mild cognitive impairment are currently attracting considerable interest. It is...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146132/ https://www.ncbi.nlm.nih.gov/pubmed/25206685 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.05.007 |
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author | Yin, Changhao Li, Siou Zhao, Weina Feng, Jiachun |
author_facet | Yin, Changhao Li, Siou Zhao, Weina Feng, Jiachun |
author_sort | Yin, Changhao |
collection | PubMed |
description | The rapidly increasing prevalence of cognitive impairment and Alzheimer's disease has the potential to create a major worldwide healthcare crisis. Structural MRI studies in patients with Alzheimer's disease and mild cognitive impairment are currently attracting considerable interest. It is extremely important to study early structural and metabolic changes, such as those in the hippocampus, entorhinal cortex, and gray matter structures in the medial temporal lobe, to allow the early detection of mild cognitive impairment and Alzheimer's disease. The microstructural integrity of white matter can be studied with diffusion tensor imaging. Increased mean diffusivity and decreased fractional anisotropy are found in subjects with white matter damage. Functional imaging studies with positron emission tomography tracer compounds enable detection of amyloid plaques in the living brain in patients with Alzheimer's disease. In this review, we will focus on key findings from brain imaging studies in mild cognitive impairment and Alzheimer's disease, including structural brain changes studied with MRI and white matter changes seen with diffusion tensor imaging, and other specific imaging methodologies will also be discussed. |
format | Online Article Text |
id | pubmed-4146132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41461322014-09-09 Brain imaging of mild cognitive impairment and Alzheimer's disease Yin, Changhao Li, Siou Zhao, Weina Feng, Jiachun Neural Regen Res Neurodegenerative Disease and Neural Regeneration The rapidly increasing prevalence of cognitive impairment and Alzheimer's disease has the potential to create a major worldwide healthcare crisis. Structural MRI studies in patients with Alzheimer's disease and mild cognitive impairment are currently attracting considerable interest. It is extremely important to study early structural and metabolic changes, such as those in the hippocampus, entorhinal cortex, and gray matter structures in the medial temporal lobe, to allow the early detection of mild cognitive impairment and Alzheimer's disease. The microstructural integrity of white matter can be studied with diffusion tensor imaging. Increased mean diffusivity and decreased fractional anisotropy are found in subjects with white matter damage. Functional imaging studies with positron emission tomography tracer compounds enable detection of amyloid plaques in the living brain in patients with Alzheimer's disease. In this review, we will focus on key findings from brain imaging studies in mild cognitive impairment and Alzheimer's disease, including structural brain changes studied with MRI and white matter changes seen with diffusion tensor imaging, and other specific imaging methodologies will also be discussed. Medknow Publications & Media Pvt Ltd 2013-02-15 /pmc/articles/PMC4146132/ /pubmed/25206685 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.05.007 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Neurodegenerative Disease and Neural Regeneration Yin, Changhao Li, Siou Zhao, Weina Feng, Jiachun Brain imaging of mild cognitive impairment and Alzheimer's disease |
title | Brain imaging of mild cognitive impairment and Alzheimer's disease |
title_full | Brain imaging of mild cognitive impairment and Alzheimer's disease |
title_fullStr | Brain imaging of mild cognitive impairment and Alzheimer's disease |
title_full_unstemmed | Brain imaging of mild cognitive impairment and Alzheimer's disease |
title_short | Brain imaging of mild cognitive impairment and Alzheimer's disease |
title_sort | brain imaging of mild cognitive impairment and alzheimer's disease |
topic | Neurodegenerative Disease and Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146132/ https://www.ncbi.nlm.nih.gov/pubmed/25206685 http://dx.doi.org/10.3969/j.issn.1673-5374.2013.05.007 |
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