Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease

Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson's disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson's disease dyskinesia in rats, and treated these animals with Comp...

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Autores principales: Teng, Long, Hong, Fang, Zhang, Chenguang, He, Jiancheng, Wang, Haiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Research and Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146199/
https://www.ncbi.nlm.nih.gov/pubmed/25206828
http://dx.doi.org/10.4103/1673-5374.128246
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author Teng, Long
Hong, Fang
Zhang, Chenguang
He, Jiancheng
Wang, Haiying
author_facet Teng, Long
Hong, Fang
Zhang, Chenguang
He, Jiancheng
Wang, Haiying
author_sort Teng, Long
collection PubMed
description Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson's disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson's disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes, and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1, an inhibitory amino acid neurotransmitter gene, in the corpus striatum. In addition, Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson's disease rats. These experimental findings indicate that Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease by modulating neurotransmitter signaling in the corpus striatum.
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spelling pubmed-41461992014-09-09 Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease Teng, Long Hong, Fang Zhang, Chenguang He, Jiancheng Wang, Haiying Neural Regen Res Research and Report Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson's disease and levodopa-induced dyskinesia; however, the mechanisms remain unclear. In this study, we established a model of Parkinson's disease dyskinesia in rats, and treated these animals with Compound Formula Rehmannia. Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes, and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1, an inhibitory amino acid neurotransmitter gene, in the corpus striatum. In addition, Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson's disease rats. These experimental findings indicate that Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease by modulating neurotransmitter signaling in the corpus striatum. Medknow Publications & Media Pvt Ltd 2014-02-15 /pmc/articles/PMC4146199/ /pubmed/25206828 http://dx.doi.org/10.4103/1673-5374.128246 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report
Teng, Long
Hong, Fang
Zhang, Chenguang
He, Jiancheng
Wang, Haiying
Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease
title Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease
title_full Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease
title_fullStr Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease
title_full_unstemmed Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease
title_short Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease
title_sort compound formula rehmannia alleviates levodopa-induced dyskinesia in parkinson's disease
topic Research and Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146199/
https://www.ncbi.nlm.nih.gov/pubmed/25206828
http://dx.doi.org/10.4103/1673-5374.128246
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