Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury

To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 10(6...

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Autores principales: Anbari, Fatemeh, Khalili, Mohammad Ali, Bahrami, Ahmad Reza, Khoradmehr, Arezoo, Sadeghian, Fatemeh, Fesahat, Farzaneh, Nabi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Research and Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146223/
https://www.ncbi.nlm.nih.gov/pubmed/25206912
http://dx.doi.org/10.4103/1673-5374.133133
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author Anbari, Fatemeh
Khalili, Mohammad Ali
Bahrami, Ahmad Reza
Khoradmehr, Arezoo
Sadeghian, Fatemeh
Fesahat, Farzaneh
Nabi, Ali
author_facet Anbari, Fatemeh
Khalili, Mohammad Ali
Bahrami, Ahmad Reza
Khoradmehr, Arezoo
Sadeghian, Fatemeh
Fesahat, Farzaneh
Nabi, Ali
author_sort Anbari, Fatemeh
collection PubMed
description To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 10(6) rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells.
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spelling pubmed-41462232014-09-09 Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury Anbari, Fatemeh Khalili, Mohammad Ali Bahrami, Ahmad Reza Khoradmehr, Arezoo Sadeghian, Fatemeh Fesahat, Farzaneh Nabi, Ali Neural Regen Res Research and Report To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 10(6) rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells. Medknow Publications & Media Pvt Ltd 2014-05-01 /pmc/articles/PMC4146223/ /pubmed/25206912 http://dx.doi.org/10.4103/1673-5374.133133 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report
Anbari, Fatemeh
Khalili, Mohammad Ali
Bahrami, Ahmad Reza
Khoradmehr, Arezoo
Sadeghian, Fatemeh
Fesahat, Farzaneh
Nabi, Ali
Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury
title Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury
title_full Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury
title_fullStr Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury
title_full_unstemmed Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury
title_short Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury
title_sort intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury
topic Research and Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146223/
https://www.ncbi.nlm.nih.gov/pubmed/25206912
http://dx.doi.org/10.4103/1673-5374.133133
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