Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease

Previous studies have confirmed that heat shock protein 90 overexpression can lead to dopaminergic neuronal death. This study was designed to further investigate what effects are produced by heat shock protein 90 after endurance exercise training. Immunohistochemistry results showed that exercise tr...

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Autores principales: Erekat, Nour, Al-Khatib, Ahed, Al-Jarrah, Muhammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Technical Updates
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146229/
https://www.ncbi.nlm.nih.gov/pubmed/25206864
http://dx.doi.org/10.4103/1673-5374.130105
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author Erekat, Nour
Al-Khatib, Ahed
Al-Jarrah, Muhammed
author_facet Erekat, Nour
Al-Khatib, Ahed
Al-Jarrah, Muhammed
author_sort Erekat, Nour
collection PubMed
description Previous studies have confirmed that heat shock protein 90 overexpression can lead to dopaminergic neuronal death. This study was designed to further investigate what effects are produced by heat shock protein 90 after endurance exercise training. Immunohistochemistry results showed that exercise training significantly inhibited heat shock protein 90 overexpression in the soleus and gastrocnemius in Parkinson's disease rats, which is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease.
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spelling pubmed-41462292014-09-09 Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease Erekat, Nour Al-Khatib, Ahed Al-Jarrah, Muhammed Neural Regen Res Technical Updates Previous studies have confirmed that heat shock protein 90 overexpression can lead to dopaminergic neuronal death. This study was designed to further investigate what effects are produced by heat shock protein 90 after endurance exercise training. Immunohistochemistry results showed that exercise training significantly inhibited heat shock protein 90 overexpression in the soleus and gastrocnemius in Parkinson's disease rats, which is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease. Medknow Publications & Media Pvt Ltd 2014-03-15 /pmc/articles/PMC4146229/ /pubmed/25206864 http://dx.doi.org/10.4103/1673-5374.130105 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technical Updates
Erekat, Nour
Al-Khatib, Ahed
Al-Jarrah, Muhammed
Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease
title Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease
title_full Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease
title_fullStr Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease
title_full_unstemmed Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease
title_short Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease
title_sort heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in parkinson's disease
topic Technical Updates
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146229/
https://www.ncbi.nlm.nih.gov/pubmed/25206864
http://dx.doi.org/10.4103/1673-5374.130105
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