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The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury
Traumatic brain injury (TBI) is the leading cause of death and disability of persons under 45 years old in the United States, affecting over 1.5 million individuals each year. It had been thought that recovery from such injuries is severely limited due to the inability of the adult brain to replace...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146269/ https://www.ncbi.nlm.nih.gov/pubmed/25206873 http://dx.doi.org/10.4103/1673-5374.131567 |
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author | Sun, Dong |
author_facet | Sun, Dong |
author_sort | Sun, Dong |
collection | PubMed |
description | Traumatic brain injury (TBI) is the leading cause of death and disability of persons under 45 years old in the United States, affecting over 1.5 million individuals each year. It had been thought that recovery from such injuries is severely limited due to the inability of the adult brain to replace damaged neurons. However, recent studies indicate that the mature mammalian central nervous system (CNS) has the potential to replenish damaged neurons by proliferation and neuronal differentiation of adult neural stem/progenitor cells residing in the neurogenic regions in the brain. Furthermore, increasing evidence indicates that these endogenous stem/progenitor cells may play regenerative and reparative roles in response to CNS injuries or diseases. In support of this notion, heightened levels of cell proliferation and neurogenesis have been observed in response to brain trauma or insults suggesting that the brain has the inherent potential to restore populations of damaged or destroyed neurons. This review will discuss the potential functions of adult neurogenesis and recent development of strategies aiming at harnessing this neurogenic capacity in order to repopulate and repair the injured brain. |
format | Online Article Text |
id | pubmed-4146269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41462692014-09-09 The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury Sun, Dong Neural Regen Res Special Issue Traumatic brain injury (TBI) is the leading cause of death and disability of persons under 45 years old in the United States, affecting over 1.5 million individuals each year. It had been thought that recovery from such injuries is severely limited due to the inability of the adult brain to replace damaged neurons. However, recent studies indicate that the mature mammalian central nervous system (CNS) has the potential to replenish damaged neurons by proliferation and neuronal differentiation of adult neural stem/progenitor cells residing in the neurogenic regions in the brain. Furthermore, increasing evidence indicates that these endogenous stem/progenitor cells may play regenerative and reparative roles in response to CNS injuries or diseases. In support of this notion, heightened levels of cell proliferation and neurogenesis have been observed in response to brain trauma or insults suggesting that the brain has the inherent potential to restore populations of damaged or destroyed neurons. This review will discuss the potential functions of adult neurogenesis and recent development of strategies aiming at harnessing this neurogenic capacity in order to repopulate and repair the injured brain. Medknow Publications & Media Pvt Ltd 2014-04-01 /pmc/articles/PMC4146269/ /pubmed/25206873 http://dx.doi.org/10.4103/1673-5374.131567 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Special Issue Sun, Dong The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury |
title | The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury |
title_full | The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury |
title_fullStr | The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury |
title_full_unstemmed | The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury |
title_short | The potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury |
title_sort | potential of endogenous neurogenesis for brain repair and regeneration following traumatic brain injury |
topic | Special Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146269/ https://www.ncbi.nlm.nih.gov/pubmed/25206873 http://dx.doi.org/10.4103/1673-5374.131567 |
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