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Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study
Many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between cerebral cortex injury and lower limb motor impairment analyzed using this technique. This study correlated neuronal injury in the cerebral cor...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146271/ https://www.ncbi.nlm.nih.gov/pubmed/25206888 http://dx.doi.org/10.4103/1673-5374.131589 |
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author | Reynolds, Alexandria M. Peters, Denise M. Vendemia, Jennifer M. C. Smith, Lenwood P. Sweet, Raymond C. Baylis, Gordon C. Krotish, Debra Fritz, Stacy L. |
author_facet | Reynolds, Alexandria M. Peters, Denise M. Vendemia, Jennifer M. C. Smith, Lenwood P. Sweet, Raymond C. Baylis, Gordon C. Krotish, Debra Fritz, Stacy L. |
author_sort | Reynolds, Alexandria M. |
collection | PubMed |
description | Many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between cerebral cortex injury and lower limb motor impairment analyzed using this technique. This study correlated neuronal injury in the cerebral cortex of 16 patients with chronic stroke based on a voxel-based lesion symptom mapping analysis. Neuronal injury in the corona radiata, caudate nucleus and putamen of patients with chronic stroke could predict walking speed. The behavioral measure scores were consistent with motor deficits expected after damage to the cortical motor system due to stroke. These findings suggest that voxel-based lesion symptom mapping may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex. |
format | Online Article Text |
id | pubmed-4146271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41462712014-09-09 Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study Reynolds, Alexandria M. Peters, Denise M. Vendemia, Jennifer M. C. Smith, Lenwood P. Sweet, Raymond C. Baylis, Gordon C. Krotish, Debra Fritz, Stacy L. Neural Regen Res Imaging in Neural Regeneration Many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between cerebral cortex injury and lower limb motor impairment analyzed using this technique. This study correlated neuronal injury in the cerebral cortex of 16 patients with chronic stroke based on a voxel-based lesion symptom mapping analysis. Neuronal injury in the corona radiata, caudate nucleus and putamen of patients with chronic stroke could predict walking speed. The behavioral measure scores were consistent with motor deficits expected after damage to the cortical motor system due to stroke. These findings suggest that voxel-based lesion symptom mapping may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex. Medknow Publications & Media Pvt Ltd 2014-04-01 /pmc/articles/PMC4146271/ /pubmed/25206888 http://dx.doi.org/10.4103/1673-5374.131589 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Imaging in Neural Regeneration Reynolds, Alexandria M. Peters, Denise M. Vendemia, Jennifer M. C. Smith, Lenwood P. Sweet, Raymond C. Baylis, Gordon C. Krotish, Debra Fritz, Stacy L. Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study |
title | Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study |
title_full | Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study |
title_fullStr | Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study |
title_full_unstemmed | Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study |
title_short | Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study |
title_sort | neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study |
topic | Imaging in Neural Regeneration |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146271/ https://www.ncbi.nlm.nih.gov/pubmed/25206888 http://dx.doi.org/10.4103/1673-5374.131589 |
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