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Houshiheisan compound prescription protects neurovascular units after cerebral ischemia

Houshiheisan is composed of wind-dispelling (chrysanthemun flower, divaricate saposhnikovia root, Manchurian wild ginger, cassia twig, Szechwan lovage rhizome, and platycodon root) and deficiency-nourishing (ginseng, Chinese angelica, large-head atractylodes rhizome, Indian bread, and zingiber) drug...

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Autores principales: Wang, Haizheng, Wang, Lei, Zhang, Nan, Zhang, Qi, Zhao, Hui, Zhang, Qiuxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146281/
https://www.ncbi.nlm.nih.gov/pubmed/25206882
http://dx.doi.org/10.4103/1673-5374.131580
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author Wang, Haizheng
Wang, Lei
Zhang, Nan
Zhang, Qi
Zhao, Hui
Zhang, Qiuxia
author_facet Wang, Haizheng
Wang, Lei
Zhang, Nan
Zhang, Qi
Zhao, Hui
Zhang, Qiuxia
author_sort Wang, Haizheng
collection PubMed
description Houshiheisan is composed of wind-dispelling (chrysanthemun flower, divaricate saposhnikovia root, Manchurian wild ginger, cassia twig, Szechwan lovage rhizome, and platycodon root) and deficiency-nourishing (ginseng, Chinese angelica, large-head atractylodes rhizome, Indian bread, and zingiber) drugs. In this study, we assumed these drugs have protective effects against cerebral ischemia, on neurovascular units. Houshiheisan was intragastrically administered in a rat model of focal cerebral ischemia. Hematoxylin-eosin staining, transmission electron microscopy, immunofluorescence staining, and western blot assays showed that Houshiheisan reduced pathological injury to the ischemic penumbra, protected neurovascular units, visibly up-regulated neuronal nuclear antigen expression, and down-regulated amyloid precursor protein and amyloid-β 42 expression. Wind-dispelling and deficiency-nourishing drugs maintained NeuN expression to varying degrees, but did not affect amyloid precursor protein or amyloid-β 42 expression in the ischemic penumbra. Our results suggest that the compound prescription Houshiheisan effectively suppresses abnormal amyloid precursor protein accumulation, reduces amyloid substance deposition, maintains stabilization of the internal environment of neurovascular units, and minimizes injury to neurovascular units in the ischemic penumbra.
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spelling pubmed-41462812014-09-09 Houshiheisan compound prescription protects neurovascular units after cerebral ischemia Wang, Haizheng Wang, Lei Zhang, Nan Zhang, Qi Zhao, Hui Zhang, Qiuxia Neural Regen Res Invited Review Houshiheisan is composed of wind-dispelling (chrysanthemun flower, divaricate saposhnikovia root, Manchurian wild ginger, cassia twig, Szechwan lovage rhizome, and platycodon root) and deficiency-nourishing (ginseng, Chinese angelica, large-head atractylodes rhizome, Indian bread, and zingiber) drugs. In this study, we assumed these drugs have protective effects against cerebral ischemia, on neurovascular units. Houshiheisan was intragastrically administered in a rat model of focal cerebral ischemia. Hematoxylin-eosin staining, transmission electron microscopy, immunofluorescence staining, and western blot assays showed that Houshiheisan reduced pathological injury to the ischemic penumbra, protected neurovascular units, visibly up-regulated neuronal nuclear antigen expression, and down-regulated amyloid precursor protein and amyloid-β 42 expression. Wind-dispelling and deficiency-nourishing drugs maintained NeuN expression to varying degrees, but did not affect amyloid precursor protein or amyloid-β 42 expression in the ischemic penumbra. Our results suggest that the compound prescription Houshiheisan effectively suppresses abnormal amyloid precursor protein accumulation, reduces amyloid substance deposition, maintains stabilization of the internal environment of neurovascular units, and minimizes injury to neurovascular units in the ischemic penumbra. Medknow Publications & Media Pvt Ltd 2014-04-01 /pmc/articles/PMC4146281/ /pubmed/25206882 http://dx.doi.org/10.4103/1673-5374.131580 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Review
Wang, Haizheng
Wang, Lei
Zhang, Nan
Zhang, Qi
Zhao, Hui
Zhang, Qiuxia
Houshiheisan compound prescription protects neurovascular units after cerebral ischemia
title Houshiheisan compound prescription protects neurovascular units after cerebral ischemia
title_full Houshiheisan compound prescription protects neurovascular units after cerebral ischemia
title_fullStr Houshiheisan compound prescription protects neurovascular units after cerebral ischemia
title_full_unstemmed Houshiheisan compound prescription protects neurovascular units after cerebral ischemia
title_short Houshiheisan compound prescription protects neurovascular units after cerebral ischemia
title_sort houshiheisan compound prescription protects neurovascular units after cerebral ischemia
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146281/
https://www.ncbi.nlm.nih.gov/pubmed/25206882
http://dx.doi.org/10.4103/1673-5374.131580
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