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Houshiheisan compound prescription protects neurovascular units after cerebral ischemia
Houshiheisan is composed of wind-dispelling (chrysanthemun flower, divaricate saposhnikovia root, Manchurian wild ginger, cassia twig, Szechwan lovage rhizome, and platycodon root) and deficiency-nourishing (ginseng, Chinese angelica, large-head atractylodes rhizome, Indian bread, and zingiber) drug...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146281/ https://www.ncbi.nlm.nih.gov/pubmed/25206882 http://dx.doi.org/10.4103/1673-5374.131580 |
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author | Wang, Haizheng Wang, Lei Zhang, Nan Zhang, Qi Zhao, Hui Zhang, Qiuxia |
author_facet | Wang, Haizheng Wang, Lei Zhang, Nan Zhang, Qi Zhao, Hui Zhang, Qiuxia |
author_sort | Wang, Haizheng |
collection | PubMed |
description | Houshiheisan is composed of wind-dispelling (chrysanthemun flower, divaricate saposhnikovia root, Manchurian wild ginger, cassia twig, Szechwan lovage rhizome, and platycodon root) and deficiency-nourishing (ginseng, Chinese angelica, large-head atractylodes rhizome, Indian bread, and zingiber) drugs. In this study, we assumed these drugs have protective effects against cerebral ischemia, on neurovascular units. Houshiheisan was intragastrically administered in a rat model of focal cerebral ischemia. Hematoxylin-eosin staining, transmission electron microscopy, immunofluorescence staining, and western blot assays showed that Houshiheisan reduced pathological injury to the ischemic penumbra, protected neurovascular units, visibly up-regulated neuronal nuclear antigen expression, and down-regulated amyloid precursor protein and amyloid-β 42 expression. Wind-dispelling and deficiency-nourishing drugs maintained NeuN expression to varying degrees, but did not affect amyloid precursor protein or amyloid-β 42 expression in the ischemic penumbra. Our results suggest that the compound prescription Houshiheisan effectively suppresses abnormal amyloid precursor protein accumulation, reduces amyloid substance deposition, maintains stabilization of the internal environment of neurovascular units, and minimizes injury to neurovascular units in the ischemic penumbra. |
format | Online Article Text |
id | pubmed-4146281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41462812014-09-09 Houshiheisan compound prescription protects neurovascular units after cerebral ischemia Wang, Haizheng Wang, Lei Zhang, Nan Zhang, Qi Zhao, Hui Zhang, Qiuxia Neural Regen Res Invited Review Houshiheisan is composed of wind-dispelling (chrysanthemun flower, divaricate saposhnikovia root, Manchurian wild ginger, cassia twig, Szechwan lovage rhizome, and platycodon root) and deficiency-nourishing (ginseng, Chinese angelica, large-head atractylodes rhizome, Indian bread, and zingiber) drugs. In this study, we assumed these drugs have protective effects against cerebral ischemia, on neurovascular units. Houshiheisan was intragastrically administered in a rat model of focal cerebral ischemia. Hematoxylin-eosin staining, transmission electron microscopy, immunofluorescence staining, and western blot assays showed that Houshiheisan reduced pathological injury to the ischemic penumbra, protected neurovascular units, visibly up-regulated neuronal nuclear antigen expression, and down-regulated amyloid precursor protein and amyloid-β 42 expression. Wind-dispelling and deficiency-nourishing drugs maintained NeuN expression to varying degrees, but did not affect amyloid precursor protein or amyloid-β 42 expression in the ischemic penumbra. Our results suggest that the compound prescription Houshiheisan effectively suppresses abnormal amyloid precursor protein accumulation, reduces amyloid substance deposition, maintains stabilization of the internal environment of neurovascular units, and minimizes injury to neurovascular units in the ischemic penumbra. Medknow Publications & Media Pvt Ltd 2014-04-01 /pmc/articles/PMC4146281/ /pubmed/25206882 http://dx.doi.org/10.4103/1673-5374.131580 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Wang, Haizheng Wang, Lei Zhang, Nan Zhang, Qi Zhao, Hui Zhang, Qiuxia Houshiheisan compound prescription protects neurovascular units after cerebral ischemia |
title | Houshiheisan compound prescription protects neurovascular units after cerebral ischemia |
title_full | Houshiheisan compound prescription protects neurovascular units after cerebral ischemia |
title_fullStr | Houshiheisan compound prescription protects neurovascular units after cerebral ischemia |
title_full_unstemmed | Houshiheisan compound prescription protects neurovascular units after cerebral ischemia |
title_short | Houshiheisan compound prescription protects neurovascular units after cerebral ischemia |
title_sort | houshiheisan compound prescription protects neurovascular units after cerebral ischemia |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146281/ https://www.ncbi.nlm.nih.gov/pubmed/25206882 http://dx.doi.org/10.4103/1673-5374.131580 |
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