Autophagy: a double-edged sword for neuronal survival after cerebral ischemia

Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after c...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Wenqi, Sun, Yinyi, Liu, Kangyong, Sun, Xiaojiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146291/
https://www.ncbi.nlm.nih.gov/pubmed/25206784
http://dx.doi.org/10.4103/1673-5374.135329
_version_ 1782332327468204032
author Chen, Wenqi
Sun, Yinyi
Liu, Kangyong
Sun, Xiaojiang
author_facet Chen, Wenqi
Sun, Yinyi
Liu, Kangyong
Sun, Xiaojiang
author_sort Chen, Wenqi
collection PubMed
description Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.
format Online
Article
Text
id pubmed-4146291
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-41462912014-09-09 Autophagy: a double-edged sword for neuronal survival after cerebral ischemia Chen, Wenqi Sun, Yinyi Liu, Kangyong Sun, Xiaojiang Neural Regen Res Review Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects. Medknow Publications & Media Pvt Ltd 2014-06-15 /pmc/articles/PMC4146291/ /pubmed/25206784 http://dx.doi.org/10.4103/1673-5374.135329 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Chen, Wenqi
Sun, Yinyi
Liu, Kangyong
Sun, Xiaojiang
Autophagy: a double-edged sword for neuronal survival after cerebral ischemia
title Autophagy: a double-edged sword for neuronal survival after cerebral ischemia
title_full Autophagy: a double-edged sword for neuronal survival after cerebral ischemia
title_fullStr Autophagy: a double-edged sword for neuronal survival after cerebral ischemia
title_full_unstemmed Autophagy: a double-edged sword for neuronal survival after cerebral ischemia
title_short Autophagy: a double-edged sword for neuronal survival after cerebral ischemia
title_sort autophagy: a double-edged sword for neuronal survival after cerebral ischemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146291/
https://www.ncbi.nlm.nih.gov/pubmed/25206784
http://dx.doi.org/10.4103/1673-5374.135329
work_keys_str_mv AT chenwenqi autophagyadoubleedgedswordforneuronalsurvivalaftercerebralischemia
AT sunyinyi autophagyadoubleedgedswordforneuronalsurvivalaftercerebralischemia
AT liukangyong autophagyadoubleedgedswordforneuronalsurvivalaftercerebralischemia
AT sunxiaojiang autophagyadoubleedgedswordforneuronalsurvivalaftercerebralischemia

Ejemplares similares