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Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits
Previous studies have shown that, anode block electrical stimulation of the sacral nerve root can produce physiological urination and reconstruct urinary bladder function in rabbits. However, whether long-term anode block electrical stimulation causes damage to the sacral nerve root remains unclear,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146294/ https://www.ncbi.nlm.nih.gov/pubmed/25206785 http://dx.doi.org/10.4103/1673-5374.135327 |
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author | Yan, Peng Yang, Xiaohong Yang, Xiaoyu Zheng, Weidong Tan, Yunbing |
author_facet | Yan, Peng Yang, Xiaohong Yang, Xiaoyu Zheng, Weidong Tan, Yunbing |
author_sort | Yan, Peng |
collection | PubMed |
description | Previous studies have shown that, anode block electrical stimulation of the sacral nerve root can produce physiological urination and reconstruct urinary bladder function in rabbits. However, whether long-term anode block electrical stimulation causes damage to the sacral nerve root remains unclear, and needs further investigation. In this study, a complete spinal cord injury model was established in New Zealand white rabbits through T(9–10) segment transection. Rabbits were given continuous electrical stimulation for a short period and then chronic stimulation for a longer period. Results showed that compared with normal rabbits, the structure of nerve cells in the anterior sacral nerve roots was unchanged in spinal cord injury rabbits after electrical stimulation. There was no significant difference in the expression of apoptosis-related proteins such as Bax, Caspase-3, and Bcl-2. Experimental findings indicate that neurons in the rabbit sacral nerve roots tolerate electrical stimulation, even after long-term anode block electrical stimulation. |
format | Online Article Text |
id | pubmed-4146294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41462942014-09-09 Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits Yan, Peng Yang, Xiaohong Yang, Xiaoyu Zheng, Weidong Tan, Yunbing Neural Regen Res Research and Report Previous studies have shown that, anode block electrical stimulation of the sacral nerve root can produce physiological urination and reconstruct urinary bladder function in rabbits. However, whether long-term anode block electrical stimulation causes damage to the sacral nerve root remains unclear, and needs further investigation. In this study, a complete spinal cord injury model was established in New Zealand white rabbits through T(9–10) segment transection. Rabbits were given continuous electrical stimulation for a short period and then chronic stimulation for a longer period. Results showed that compared with normal rabbits, the structure of nerve cells in the anterior sacral nerve roots was unchanged in spinal cord injury rabbits after electrical stimulation. There was no significant difference in the expression of apoptosis-related proteins such as Bax, Caspase-3, and Bcl-2. Experimental findings indicate that neurons in the rabbit sacral nerve roots tolerate electrical stimulation, even after long-term anode block electrical stimulation. Medknow Publications & Media Pvt Ltd 2014-06-15 /pmc/articles/PMC4146294/ /pubmed/25206785 http://dx.doi.org/10.4103/1673-5374.135327 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research and Report Yan, Peng Yang, Xiaohong Yang, Xiaoyu Zheng, Weidong Tan, Yunbing Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits |
title | Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits |
title_full | Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits |
title_fullStr | Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits |
title_full_unstemmed | Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits |
title_short | Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits |
title_sort | prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits |
topic | Research and Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146294/ https://www.ncbi.nlm.nih.gov/pubmed/25206785 http://dx.doi.org/10.4103/1673-5374.135327 |
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