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Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits

Previous studies have shown that, anode block electrical stimulation of the sacral nerve root can produce physiological urination and reconstruct urinary bladder function in rabbits. However, whether long-term anode block electrical stimulation causes damage to the sacral nerve root remains unclear,...

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Detalles Bibliográficos
Autores principales: Yan, Peng, Yang, Xiaohong, Yang, Xiaoyu, Zheng, Weidong, Tan, Yunbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146294/
https://www.ncbi.nlm.nih.gov/pubmed/25206785
http://dx.doi.org/10.4103/1673-5374.135327
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author Yan, Peng
Yang, Xiaohong
Yang, Xiaoyu
Zheng, Weidong
Tan, Yunbing
author_facet Yan, Peng
Yang, Xiaohong
Yang, Xiaoyu
Zheng, Weidong
Tan, Yunbing
author_sort Yan, Peng
collection PubMed
description Previous studies have shown that, anode block electrical stimulation of the sacral nerve root can produce physiological urination and reconstruct urinary bladder function in rabbits. However, whether long-term anode block electrical stimulation causes damage to the sacral nerve root remains unclear, and needs further investigation. In this study, a complete spinal cord injury model was established in New Zealand white rabbits through T(9–10) segment transection. Rabbits were given continuous electrical stimulation for a short period and then chronic stimulation for a longer period. Results showed that compared with normal rabbits, the structure of nerve cells in the anterior sacral nerve roots was unchanged in spinal cord injury rabbits after electrical stimulation. There was no significant difference in the expression of apoptosis-related proteins such as Bax, Caspase-3, and Bcl-2. Experimental findings indicate that neurons in the rabbit sacral nerve roots tolerate electrical stimulation, even after long-term anode block electrical stimulation.
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spelling pubmed-41462942014-09-09 Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits Yan, Peng Yang, Xiaohong Yang, Xiaoyu Zheng, Weidong Tan, Yunbing Neural Regen Res Research and Report Previous studies have shown that, anode block electrical stimulation of the sacral nerve root can produce physiological urination and reconstruct urinary bladder function in rabbits. However, whether long-term anode block electrical stimulation causes damage to the sacral nerve root remains unclear, and needs further investigation. In this study, a complete spinal cord injury model was established in New Zealand white rabbits through T(9–10) segment transection. Rabbits were given continuous electrical stimulation for a short period and then chronic stimulation for a longer period. Results showed that compared with normal rabbits, the structure of nerve cells in the anterior sacral nerve roots was unchanged in spinal cord injury rabbits after electrical stimulation. There was no significant difference in the expression of apoptosis-related proteins such as Bax, Caspase-3, and Bcl-2. Experimental findings indicate that neurons in the rabbit sacral nerve roots tolerate electrical stimulation, even after long-term anode block electrical stimulation. Medknow Publications & Media Pvt Ltd 2014-06-15 /pmc/articles/PMC4146294/ /pubmed/25206785 http://dx.doi.org/10.4103/1673-5374.135327 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report
Yan, Peng
Yang, Xiaohong
Yang, Xiaoyu
Zheng, Weidong
Tan, Yunbing
Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits
title Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits
title_full Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits
title_fullStr Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits
title_full_unstemmed Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits
title_short Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits
title_sort prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits
topic Research and Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146294/
https://www.ncbi.nlm.nih.gov/pubmed/25206785
http://dx.doi.org/10.4103/1673-5374.135327
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