L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments

Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exh...

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Autores principales: Avsar, Ümmü Zeynep, Avsar, Umit, Aydin, Ali, Yayla, Muhammed, Ozturkkaragoz, Berna, Un, Harun, Saritemur, Murat, Mercantepe, Tolga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Research and Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146308/
https://www.ncbi.nlm.nih.gov/pubmed/25206754
http://dx.doi.org/10.4103/1673-5374.133163
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author Avsar, Ümmü Zeynep
Avsar, Umit
Aydin, Ali
Yayla, Muhammed
Ozturkkaragoz, Berna
Un, Harun
Saritemur, Murat
Mercantepe, Tolga
author_facet Avsar, Ümmü Zeynep
Avsar, Umit
Aydin, Ali
Yayla, Muhammed
Ozturkkaragoz, Berna
Un, Harun
Saritemur, Murat
Mercantepe, Tolga
author_sort Avsar, Ümmü Zeynep
collection PubMed
description Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved significantly. These findings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.
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spelling pubmed-41463082014-09-09 L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments Avsar, Ümmü Zeynep Avsar, Umit Aydin, Ali Yayla, Muhammed Ozturkkaragoz, Berna Un, Harun Saritemur, Murat Mercantepe, Tolga Neural Regen Res Research and Report Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved significantly. These findings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats. Medknow Publications & Media Pvt Ltd 2014-05-15 /pmc/articles/PMC4146308/ /pubmed/25206754 http://dx.doi.org/10.4103/1673-5374.133163 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report
Avsar, Ümmü Zeynep
Avsar, Umit
Aydin, Ali
Yayla, Muhammed
Ozturkkaragoz, Berna
Un, Harun
Saritemur, Murat
Mercantepe, Tolga
L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments
title L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments
title_full L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments
title_fullStr L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments
title_full_unstemmed L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments
title_short L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments
title_sort l-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments
topic Research and Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146308/
https://www.ncbi.nlm.nih.gov/pubmed/25206754
http://dx.doi.org/10.4103/1673-5374.133163
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