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Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury

The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury. Adult Sprague-Dawley rats with...

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Autores principales: Aloe, Luigi, Bianchi, Patrizia, De Bellis, Alberto, Soligo, Marzia, Rocco, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146309/
https://www.ncbi.nlm.nih.gov/pubmed/25206755
http://dx.doi.org/10.4103/1673-5374.133161
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author Aloe, Luigi
Bianchi, Patrizia
De Bellis, Alberto
Soligo, Marzia
Rocco, Maria Luisa
author_facet Aloe, Luigi
Bianchi, Patrizia
De Bellis, Alberto
Soligo, Marzia
Rocco, Maria Luisa
author_sort Aloe, Luigi
collection PubMed
description The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury. Adult Sprague-Dawley rats with intact and injured spinal cord received daily intranasal nerve growth factor administration in both nostrils for 1 day or for 3 consecutive weeks. We found an increased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats, while daily treatment for 3 weeks in a model of spinal cord injury improved the deficits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors. These outcomes suggest that the intranasal nerve growth factor bypasses blood-brain barrier and affects spinal cord neurons in spinal cord injury. They also suggest exploiting the possible therapeutic role of intranasally delivered nerve growth factor for the neuroprotection of damaged spinal nerve cells.
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spelling pubmed-41463092014-09-09 Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury Aloe, Luigi Bianchi, Patrizia De Bellis, Alberto Soligo, Marzia Rocco, Maria Luisa Neural Regen Res Research and Report The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury. Adult Sprague-Dawley rats with intact and injured spinal cord received daily intranasal nerve growth factor administration in both nostrils for 1 day or for 3 consecutive weeks. We found an increased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats, while daily treatment for 3 weeks in a model of spinal cord injury improved the deficits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors. These outcomes suggest that the intranasal nerve growth factor bypasses blood-brain barrier and affects spinal cord neurons in spinal cord injury. They also suggest exploiting the possible therapeutic role of intranasally delivered nerve growth factor for the neuroprotection of damaged spinal nerve cells. Medknow Publications & Media Pvt Ltd 2014-05-15 /pmc/articles/PMC4146309/ /pubmed/25206755 http://dx.doi.org/10.4103/1673-5374.133161 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report
Aloe, Luigi
Bianchi, Patrizia
De Bellis, Alberto
Soligo, Marzia
Rocco, Maria Luisa
Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury
title Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury
title_full Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury
title_fullStr Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury
title_full_unstemmed Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury
title_short Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury
title_sort intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury
topic Research and Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146309/
https://www.ncbi.nlm.nih.gov/pubmed/25206755
http://dx.doi.org/10.4103/1673-5374.133161
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