Membrane Type 1–Matrix Metalloproteinase/Akt Signaling Axis Modulates TNF-α-Induced Procoagulant Activity and Apoptosis in Endothelial Cells

Membrane type 1–matrix metalloproteinase (MT1-MMP) functions as a signaling molecule in addition to a proteolytic enzyme. Our hypothesis was that MT1-MMP cooperates with protein kinase B (Akt) in tumor necrosis factor (TNF)-α-induced signaling pathways of vascular responses, including tissue factor...

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Detalles Bibliográficos
Autores principales: Ohkawara, Hiroshi, Ishibashi, Toshiyuki, Sugimoto, Koichi, Ikeda, Kazuhiko, Ogawa, Kazuei, Takeishi, Yasuchika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146507/
https://www.ncbi.nlm.nih.gov/pubmed/25162582
http://dx.doi.org/10.1371/journal.pone.0105697

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